proline, glutamate and leucine rich protein 1 ; Homo sapiens






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1 11481323 Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. J Biol Chem 2001 Oct 12 4
2 12682072 Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein. J Biol Chem 2003 Jun 13 4
3 14963108 Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc. Mol Endocrinol 2004 May 1
4 15087130 Cloning and functional characterization of PELP1/MNAR promoter. Gene 2004 Apr 14 3
5 15466214 Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence. Cancer Res 2004 Oct 1 2
6 15579769 Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors. J Clin Endocrinol Metab 2004 Dec 1
7 16140940 Functional implications of altered subcellular localization of PELP1 in breast cancer cells. Cancer Res 2005 Sep 1 1
8 16141397 Cloning, expression, and localization of MNAR/PELP1 in rodent brain: colocalization in estrogen receptor-alpha- but not in gonadotropin-releasing hormone-positive neurons. Endocrinology 2005 Dec 3
9 16297421 Characterization of MNAR expression. Steroids 2006 Apr 1
10 16505095 Altered localization of a coactivator sensitizes breast cancer cells to tumor necrosis factor-induced apoptosis. Mol Cancer Ther 2006 Feb 2
11 16574651 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway. J Biol Chem 2006 Jun 2 10
12 17142998 Cloning, distribution, and colocalization of MNAR/PELP1 with glucocorticoid receptors in primate and nonprimate brain. Neuroendocrinology 2006 1
13 17194752 Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase. Mol Cell Biol 2007 Mar 6
14 17525794 Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR. Nucl Recept Signal 2007 May 17 2
15 17545633 Oncogenic potential of the nuclear receptor coregulator proline-, glutamic acid-, leucine-rich protein 1/modulator of the nongenomic actions of the estrogen receptor. Cancer Res 2007 Jun 1 1
16 17804729 Identifying the estrogen receptor coactivator PELP1 in autophagosomes. Cancer Res 2007 Sep 1 7
17 18000392 Delivery of cytoplasmic proteins to autophagosomes. Autophagy 2008 Jan 5
18 18059220 Differential expression of hormonal and growth factor receptors in salivary duct carcinomas: biologic significance and potential role in therapeutic stratification of patients. Am J Surg Pathol 2007 Nov 1
19 18079323 Modulation of in situ estrogen synthesis by proline-, glutamic acid-, and leucine-rich protein-1: potential estrogen receptor autocrine signaling loop in breast cancer cells. Mol Endocrinol 2008 Mar 1
20 18261753 MNAR plays an important role in ERa activation of Src/MAPK and PI3K/Akt signaling pathways. Steroids 2008 Oct 1
21 18505929 Growth factor regulation of estrogen receptor coregulator PELP1 functions via Protein Kinase A pathway. Mol Cancer Res 2008 May 1
22 18571832 PELP1--a novel estrogen receptor-interacting protein. Mol Cell Endocrinol 2008 Aug 13 5
23 19048289 Expression of estrogen receptor co-regulators NCoR and PELP1 in epithelial cells and myofibroblasts of colorectal carcinomas: cytoplasmic translocation of NCoR in epithelial cells correlates with better [corrected] prognosis. Virchows Arch 2009 Jan 2
24 19470742 Extranuclear coactivator signaling confers insensitivity to tamoxifen. Clin Cancer Res 2009 Jun 15 1
25 19605405 The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signaling. Cancer Res 2009 Jul 15 1
26 20442285 Involvement of the tubulin tyrosine ligase-like family member 4 polyglutamylase in PELP1 polyglutamylation and chromatin remodeling in pancreatic cancer cells. Cancer Res 2010 May 15 2
27 20807815 Cyclin-dependent kinase-mediated phosphorylation plays a critical role in the oncogenic functions of PELP1. Cancer Res 2010 Sep 15 5
28 21184269 Significance of ER-Src axis in hormonal therapy resistance. Breast Cancer Res Treat 2011 Nov 4
29 21421858 Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis. Clin Cancer Res 2011 Apr 15 6
30 21695158 Regulation of rDNA transcription by proto-oncogene PELP1. PLoS One 2011 1
31 21834972 Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells. Breast Cancer Res 2011 Aug 11 1
32 22403175 Central role for PELP1 in nonandrogenic activation of the androgen receptor in prostate cancer. Mol Endocrinol 2012 Apr 1
33 22812534 Targeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer. Breast Cancer Res 2012 Jul 19 2
34 22992372 Integration of ERα-PELP1-HER2 signaling by LSD1 (KDM1A/AOF2) offers combinatorial therapeutic opportunities to circumventing hormone resistance in breast cancer. Breast Cancer Res 2012 Sep 17 2
35 22992812 PELP1/MNAR suppression inhibits proliferation and metastasis of endometrial carcinoma cells. Oncol Rep 2012 Dec 4
36 23486015 PELP1 oncogenic functions involve CARM1 regulation. Carcinogenesis 2013 Jul 8
37 23836152 Vitamin C induces periodontal ligament progenitor cell differentiation via activation of ERK pathway mediated by PELP1. Protein Cell 2013 Aug 1
38 23975430 Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer. Oncogene 2014 Jul 10 1
39 24447537 PELP1 oncogenic functions involve alternative splicing via PRMT6. Mol Oncol 2014 Mar 1
40 24469035 Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes. Oncogene 2015 Jan 22 2
41 24688046 Inhibition of mTOR signaling reduces PELP1-mediated tumor growth and therapy resistance. Mol Cancer Ther 2014 Jun 2
42 24752897 The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1. Mol Cell Biol 2014 Jul 2
43 24786831 Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response. Cell Death Differ 2014 Sep 4
44 25789479 Cytoplasmic PELP1 and ERRgamma protect human mammary epithelial cells from Tam-induced cell death. PLoS One 2015 8
45 26211588 Increased expression of proline-, glutamic acid- and leucine-rich protein PELP1 in non-small cell lung cancer. Biomed Pharmacother 2015 Jul 1
46 26472563 Prognostic significance of proline, glutamic acid, leucine rich protein 1 (PELP1) in triple-negative breast cancer: a retrospective study on 129 cases. BMC Cancer 2015 Oct 15 2
47 26825173 Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res 2016 Mar 15 1
48 27881676 Cytoplasmic Localization of Proline, Glutamic Acid, Leucine-rich Protein 1 (PELP1) Induces Breast Epithelial Cell Migration through Up-regulation of Inhibitor of κB Kinase ϵ and Inflammatory Cross-talk with Macrophages. J Biol Chem 2017 Jan 6 3
49 30771436 Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis. Cancer Lett 2019 May 28 3
50 32037484 Estradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive Breast Cancer Cells. Horm Cancer 2020 Apr 9