paraoxonase 2 ; Homo sapiens






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1 8661009 The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics 1996 May 1 1
2 9329371 Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1997 Oct 10
3 9443862 DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease. Am J Hum Genet 1998 Jan 4
4 9699900 Genetic variation in paraoxonase-1 and paraoxonase-2 is associated with variation in plasma lipoproteins in Alberta Hutterites. Atherosclerosis 1998 Jul 1
5 9842991 Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree. Clin Genet 1998 Nov 3
6 10442677 Paraoxonase genes and disease. Ann Med 1999 Jun 1
7 10677395 Low paraoxonase activity in type II diabetes mellitus complicated by retinopathy. Clin Sci (Lond) 2000 Mar 1
8 11257265 PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients. Atherosclerosis 2001 Feb 15 5
9 11579088 Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein. J Biol Chem 2001 Nov 30 4
10 11803456 Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias. Mol Psychiatry 2002 2
11 11918623 Paraoxonase gene cluster is a genetic marker for early microvascular complications in type 1 diabetes. Diabet Med 2002 Mar 2
12 12433026 The risk of coronary artery disease in population of Taiwan is associated with Cys-Ser 311 polymorphism of human paraoxonase (PON)-2 gene. Zhonghua Yi Xue Za Zhi (Taipei) 2002 Sep 3
13 12454802 Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. Am J Hum Genet 2003 Jan 2
14 12778447 [The association of paraoxonase 2 gene C311S variant with ischemic stroke in Chinese type 2 diabetes mellitus patients]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003 Jun 3
15 12939804 [Associations of Rsa I polymorphism at the 5' flanking region of CYP2E1 and PON2 148 polymorphism in neonates with preterm delivery]. Yi Chuan Xue Bao 2003 Jun 1
16 14592851 Decreased macrophage paraoxonase 2 expression in patients with hypercholesterolemia is the result of their increased cellular cholesterol content: effect of atorvastatin therapy. Arterioscler Thromb Vasc Biol 2004 Jan 6
17 14984433 Interaction between smoking and PON2 Ser311Cys polymorphism as a determinant of the risk of myocardial infarction. Eur J Clin Invest 2004 Jan 3
18 14996478 PON1 M/L55 mutation protects high-risk patients against coronary artery disease. Int J Cardiol 2004 Mar 1
19 15544923 Paraoxonase 2 (PON2) expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate (NADPH)-oxidase-dependent mechanism during monocytes differentiation into macrophages. Free Radic Biol Med 2004 Dec 15 2
20 15772423 Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. J Lipid Res 2005 Jun 1
21 16135439 [Association of PON2 gene polymorphisms in neonates with preterm]. Yi Chuan 2002 Sep 4
22 16141008 Association of genes of lipid metabolism with measures of subclinical cardiovascular disease in the Diabetes Heart Study. J Med Genet 2005 Sep 1
23 16776623 Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia. Clin Chem Lab Med 2006 1
24 17299970 [Study of the association between paraoxonase1 55 Met/Leu, paraoxonase2 148 Ala/Gly and manganese superoxide dismutase (MnSOD) 9 Ala/Val genetic polymorphisms and coronary heart disease]. Zhonghua Liu Xing Bing Xue Za Zhi 2006 Sep 1
25 17404154 Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation. Circulation 2007 Apr 17 5
26 17557249 [Relationship between single nucleotide polymorphisms of paraoxonase 2 and stroke]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Jun 2
27 17854416 The paraoxonase gene polymorphism in stroke patients and lipid profile. Acta Neurol Scand 2008 Apr 1
28 17916643 Biological role, protein expression, subcellular localization, and oxidative stress response of paraoxonase 2 in the intestine of humans and rats. Am J Physiol Gastrointest Liver Physiol 2007 Dec 7
29 17940058 The Cys(311)Ser polymorphism of paraoxonase 2 (PON2) is associated with albumin-to-creatinine ratio (ACR) in Mexican Americans. Nephrol Dial Transplant 2008 Jan 2
30 18020951 Macrophage paraoxonase 2 (PON2) expression is upregulated by unesterified cholesterol through activation of the phosphatidylinositol 3-kinase (PI3K) pathway. Biol Chem 2007 Dec 4
31 18063859 Study of the relationship between gene polymorphisms of paraoxonase 2 and stroke in a Chinese population. Cerebrovasc Dis 2008 2
32 18347034 Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone. Infect Immun 2008 Jun 1
33 18691157 Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis. Biochem J 2008 Dec 15 9
34 18759523 Association of cys 311 ser polymorphism of paraoxonase-2 gene with the risk of coronary artery disease. Arch Iran Med 2008 Sep 4
35 19082953 Paraoxonases (PON1, PON2, PON3) analyses in vitro and in vivo in relation to cardiovascular diseases. Methods Mol Biol 2008 4
36 19091699 Paraoxonase 2 attenuates macrophage triglyceride accumulation via inhibition of diacylglycerol acyltransferase 1. J Lipid Res 2009 May 1
37 19152805 Synergistic effect of polymorphisms of paraoxonase gene cluster and arsenic exposure on electrocardiogram abnormality. Toxicol Appl Pharmacol 2009 Sep 1 1
38 19401157 Comparative expression analysis reveals differences in the regulation of intestinal paraoxonase family members. Int J Biochem Cell Biol 2009 Jul 1
39 19474728 The roles of PON1 and PON2 in cardiovascular disease and innate immunity. Curr Opin Lipidol 2009 Aug 1
40 19497963 Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta. Cardiovasc Res 2009 Oct 1 6
41 19840942 A common mutation in paraoxonase-2 results in impaired lactonase activity. J Biol Chem 2009 Dec 18 1
42 19865538 Effect of quercetin on paraoxonase 2 levels in RAW264.7 macrophages and in human monocytes--role of quercetin metabolism. Int J Mol Sci 2009 Sep 23 3
43 19925453 Paraoxonase 2 is down-regulated by the Pseudomonas aeruginosa quorumsensing signal N-(3-oxododecanoyl)-L-homoserine lactone and attenuates oxidative stress induced by pyocyanin. Biochem J 2010 Jan 27 9
44 20133274 Paraoxonase 1 R/Q alleles are associated with differential accumulation of saturated versus 20:5n3 fatty acid in human adipose tissue. J Lipid Res 2010 Jul 1
45 20458436 Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. Thromb Haemost 2010 Aug 1
46 20530481 One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity. J Biol Chem 2010 Aug 6 6
47 20582942 Paraoxonase gene mutations in amyotrophic lateral sclerosis. Ann Neurol 2010 Jul 1
48 21031320 High-performance liquid chromatography analysis of N-acyl homoserine lactone hydrolysis by paraoxonases. Methods Mol Biol 2011 1
49 21053390 Glabridin, a phytoestrogen from licorice root, up-regulates manganese superoxide dismutase, catalase and paraoxonase 2 under glucose stress. Phytother Res 2011 May 2
50 21118365 Continuous reduction of plasma paraoxonase activity with increasing dialysis vintage in hemodialysis patients. Ther Apher Dial 2010 Dec 1