| 1 | 16484774 | Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization. | Cytogenet Genome Res | 2006 |
6 |
| 2 | 17355872 | Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin. | Structure | 2007 Mar |
6 |
| 3 | 17628866 | Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins). | ChemMedChem | 2007 Oct |
2 |
| 4 | 19410538 | Ure(k)a! Sirtuins Regulate Mitochondria. | Cell | 2009 May 1 |
1 |
| 5 | 20060508 | Mitochondrial sirtuins. | Biochim Biophys Acta | 2010 Aug |
3 |
| 6 | 20157539 | Urea cycle regulation by mitochondrial sirtuin, SIRT5. | Aging (Albany NY) | 2009 Jun 29 |
3 |
| 7 | 21143562 | Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms. | Genes Cells | 2011 Feb |
1 |
| 8 | 21908771 | The first identification of lysine malonylation substrates and its regulatory enzyme. | Mol Cell Proteomics | 2011 Dec |
2 |
| 9 | 22076378 | Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. | Science | 2011 Nov 11 |
6 |
| 10 | 22263694 | Thiosuccinyl peptides as Sirt5-specific inhibitors. | J Am Chem Soc | 2012 Feb 1 |
3 |
| 11 | 22583019 | Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme. | J Med Chem | 2012 Jun 14 |
5 |
| 12 | 22585829 | Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc. | Endocrinology | 2012 Jul |
1 |
| 13 | 22767592 | The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5). | J Biol Chem | 2012 Aug 17 |
8 |
| 14 | 22849721 | Synthesis of carba-NAD and the structures of its ternary complexes with SIRT3 and SIRT5. | J Org Chem | 2012 Sep 7 |
3 |
| 15 | 22902903 | Mitochondrial sirtuins: regulators of protein acylation and metabolism. | Trends Endocrinol Metab | 2012 Sep |
1 |
| 16 | 23028781 | Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition. | PLoS One | 2012 |
18 |
| 17 | 23185430 | A molecular mechanism for direct sirtuin activation by resveratrol. | PLoS One | 2012 |
1 |
| 18 | 23195732 | Inhibition of the human deacylase Sirtuin 5 by the indole GW5074. | Bioorg Med Chem Lett | 2013 Jan 1 |
4 |
| 19 | 23806337 | SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. | Mol Cell | 2013 Jun 27 |
3 |
| 20 | 24140062 | SIRT5 desuccinylates and activates SOD1 to eliminate ROS. | Biochem Biophys Res Commun | 2013 Nov 8 |
2 |
| 21 | 24315375 | SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. | Cell Metab | 2013 Dec 3 |
4 |
| 22 | 24687991 | SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism. | FASEB J | 2014 Jul |
2 |
| 23 | 24797412 | Roles of sirtuins in the regulation of antioxidant defense and bioenergetic function of mitochondria under oxidative stress. | Free Radic Res | 2014 Sep |
1 |
| 24 | 24848608 | A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5. | Org Biomol Chem | 2014 Jul 7 |
2 |
| 25 | 24900427 | Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. | ACS Med Chem Lett | 2012 Dec 13 |
4 |
| 26 | 25032863 | Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death. | Cell Death Dis | 2014 Jul 17 |
3 |
| 27 | 25070488 | SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer. | Tumour Biol | 2014 Nov |
7 |
| 28 | 25111069 | Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors. | Angew Chem Int Ed Engl | 2014 Sep 26 |
1 |
| 29 | 25165814 | Overexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells. | PLoS One | 2014 |
1 |
| 30 | 25308486 | NAD⁺ content and its role in mitochondria. | Methods Mol Biol | 2015 |
1 |
| 31 | 25545135 | Mitochondrial sirtuins and their relationships with metabolic disease and cancer. | Antioxid Redox Signal | 2015 Apr 20 |
3 |
| 32 | 25700560 | SIRT5 regulation of ammonia-induced autophagy and mitophagy. | Autophagy | 2015 |
13 |
| 33 | 25811481 | SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase. | PLoS One | 2015 |
3 |
| 34 | 25981116 | SIRT5 prevents cigarette smoke extract-induced apoptosis in lung epithelial cells via deacetylation of FOXO3. | Cell Stress Chaperones | 2015 Sep |
1 |
| 35 | 26037200 | The orphan estrogen-related receptor alpha and metabolic regulation: new frontiers. | J Recept Signal Transduct Res | 2015 |
2 |
| 36 | 26320211 | Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation. | Mol Cell Proteomics | 2015 Nov |
1 |
| 37 | 26418815 | Novel sirtuin inhibitory warheads derived from the N(ε)-acetyl-lysine analog L-2-amino-7-carboxamidoheptanoic acid. | Org Biomol Chem | 2015 Nov 14 |
1 |
| 38 | 26574954 | Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins. | J Clin Endocrinol Metab | 2016 Jan |
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| 39 | 26635020 | Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples. | Anal Bioanal Chem | 2016 Jan |
2 |
| 40 | 26867736 | Quantitative Analysis of the Sirt5-Regulated Lysine Succinylation Proteome in Mammalian Cells. | Methods Mol Biol | 2016 |
3 |
| 41 | 27023330 | Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme. | PLoS One | 2016 |
2 |
| 42 | 27113762 | SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. | EMBO Rep | 2016 Jun |
10 |
| 43 | 27577743 | Sirtuin 5 is Anti-apoptotic and Anti-oxidative in Cultured SH-EP Neuroblastoma Cells. | Neurotox Res | 2017 Jan |
7 |
| 44 | 28004755 | STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism. | Sci Rep | 2016 Dec 22 |
1 |
| 45 | 28036303 | Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth. | Oncotarget | 2017 Jan 24 |
2 |
| 46 | 28050792 | Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders. | Mol Neurobiol | 2018 Jan |
1 |
| 47 | 28458255 | Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain. | J Biol Chem | 2017 Jun 16 |
5 |
| 48 | 28461090 | NAD<sup>+</sup> dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65. | J Autoimmun | 2017 Jul |
1 |
| 49 | 28631845 | Mild metabolic perturbations alter succinylation of mitochondrial proteins. | J Neurosci Res | 2017 Nov |
1 |
| 50 | 28707979 | Emerging Roles for SIRT5 in Metabolism and Cancer. | Antioxid Redox Signal | 2018 Mar 10 |
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