bromodomain containing 4 ; Homo sapiens






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51 24985178 [Effect of bromdomain protein 4 inhibitor GSK525762A on the proliferation and apoptosis of B-cell acute lymphoblastic leukemia cells and its mechanism]. Zhonghua Xue Ye Xue Za Zhi 2014 Jun 4
52 25097667 Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching. Epigenetics Chromatin 2014 2
53 25120803 Bromodomain 4 protein is a predictor of survival for urothelial carcinoma of bladder. Int J Clin Exp Pathol 2014 1
54 25290579 Fluorinated aromatic amino acids are sensitive 19F NMR probes for bromodomain-ligand interactions. ACS Chem Biol 2014 Dec 19 3
55 25338565 [Effect of BRD4 inhibitor GSK525762A on proliferation and apoptosis of KU812 leukemic cells and its mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2014 Oct 3
56 25340539 Phosphorylation of HPV-16 E2 at serine 243 enables binding to Brd4 and mitotic chromosomes. PLoS One 2014 4
57 25537515 Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers. Oncotarget 2015 Feb 10 1
58 25559428 Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization. J Med Chem 2015 Feb 12 2
59 25603177 BRD4 inhibitor inhibits colorectal cancer growth and metastasis. Int J Mol Sci 2015 Jan 16 1
60 25647019 BRD4 promotes pancreatic ductal adenocarcinoma cell proliferation and enhances gemcitabine resistance. Oncol Rep 2015 Apr 4
61 25678016 Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors. Bioorg Med Chem 2015 Mar 1 4
62 25703523 9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain. J Med Chem 2015 Mar 26 1
63 25788266 H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription. Oncotarget 2015 Mar 30 1
64 25941994 Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma. Epigenetics 2015 2
65 25944566 BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells. Sci Rep 2015 May 6 1
66 25946208 A Genetically Encoded FRET Probe to Detect Intranucleosomal Histone H3K9 or H3K14 Acetylation Using BRD4, a BET Family Member. ACS Chem Biol 2016 Mar 18 1
67 26045013 Phthalimide-Conjugated Ligands Promote Selective Protein Destabilization. Cancer Discov 2015 Jul 1
68 26083714 Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism. Elife 2015 Jun 17 1
69 26119939 Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors. Oncogene 2016 Apr 7 1
70 26158404 Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules. ACS Chem Biol 2015 Oct 16 1
71 26191363 BRD4 Structure-Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536. ACS Med Chem Lett 2015 Jul 9 11
72 26224795 Bromodomain-Containing Protein 4: The Epigenetic Origin of Pulmonary Arterial Hypertension. Circ Res 2015 Aug 28 3
73 26304078 [In vitro study of BRD4 inhibitor GSK525762A against primary adult common B-cell acute lymphoblastic leukemia cells in vitro]. Zhonghua Xue Ye Xue Za Zhi 2015 Jul 3
74 26416749 Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature 2015 Oct 8 1
75 26456956 Downregulation of miR-329 promotes cell invasion by regulating BRD4 and predicts poor prognosis in hepatocellular carcinoma. Tumour Biol 2016 Mar 2
76 26504077 Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction. J Biol Chem 2016 Jan 1 2
77 26536665 Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth. Oncotarget 2016 Feb 9 1
78 26546038 High-density P300 enhancers control cell state transitions. BMC Genomics 2015 Nov 6 1
79 26707881 Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer. Biochem Biophys Res Commun 2016 Jan 15 2
80 26731611 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J Med Chem 2016 Feb 25 3
81 26735842 Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins. J Med Chem 2016 Feb 25 2
82 26878240 7SK-BAF axis controls pervasive transcription at enhancers. Nat Struct Mol Biol 2016 Mar 1
83 26976114 Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628. Cancer Discov 2016 May 1
84 26983878 Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells. Mol Cancer Ther 2016 Jun 1
85 26985285 Dihydropteridinone Inhibitors of BRD4. ACS Med Chem Lett 2016 Feb 11 1
86 27007123 The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC. J Neurovirol 2016 Oct 1
87 27063978 Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study. Lancet Haematol 2016 Apr 1
88 27142751 Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors. Bioorg Med Chem Lett 2016 Jun 15 1
89 27148573 Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case. Cold Spring Harb Mol Case Stud 2015 Oct 2
90 27219867 Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains. J Med Chem 2016 Jun 9 1
91 27238211 NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds. Acta Pharmacol Sin 2016 Jul 3
92 27264992 Isoxazole-Derived Amino Acids are Bromodomain-Binding Acetyl-Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3. Angew Chem Int Ed Engl 2016 Jul 11 8
93 27266999 Development of 4,5-dihydro-benzodiazepinone derivatives as a new chemical series of BRD4 inhibitors. Eur J Med Chem 2016 Oct 4 2
94 27290915 An Overview on Small Molecule Inhibitors of BRD4. Mini Rev Med Chem 2016 4
95 27425608 Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA. Cell Rep 2016 Aug 2 1
96 27494802 Molecular docking and dynamics simulation study of flavonoids as BET bromodomain inhibitors. J Biomol Struct Dyn 2017 Aug 6
97 27496136 Single Agent and Synergistic Activity of the "First-in-Class" Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma. Mol Cancer Ther 2016 Nov 9
98 27520485 Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1. Biochem Pharmacol 2016 Oct 1 1
99 27573426 AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies. Mol Cancer Ther 2016 Nov 4
100 27580186 Design, synthesis and biological evaluation of dihydroquinoxalinone derivatives as BRD4 inhibitors. Bioorg Chem 2016 Oct 3