| 1 | 1384039 | Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries. | Proc Natl Acad Sci U S A | 1992 Oct 1 |
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| 2 | 1465135 | Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. | Nature | 1992 Dec 17 |
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| 3 | 7478553 | Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos. | Oncogene | 1995 Oct 5 |
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| 4 | 7486658 | A 115 kDa tyrosine phosphorylated protein associates with Grb-2 in activated Jurkat cells. | Ann N Y Acad Sci | 1995 Sep 7 |
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| 5 | 7492780 | The insulin receptor substrate-1-related 4PS substrate but not the interleukin-2R gamma chain is involved in interleukin-13-mediated signal transduction. | Blood | 1995 Dec 1 |
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| 6 | 7500025 | Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells. | J Exp Med | 1995 Dec 1 |
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| 7 | 7504175 | Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. | Mol Cell Biol | 1993 Dec |
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| 8 | 7506413 | Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity. | Proc Natl Acad Sci U S A | 1994 Jan 4 |
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| 9 | 7513258 | A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. | Cell | 1994 Apr 22 |
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| 10 | 7515480 | SH2 domain specificity and activity modified by a single residue. | Nature | 1994 Jun 9 |
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| 11 | 7518443 | Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2. | J Biol Chem | 1994 Jul 22 |
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| 12 | 7518560 | Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. | Mol Cell Biol | 1994 Aug |
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| 13 | 7521298 | Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs. | EMBO J | 1994 Sep 1 |
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| 14 | 7522233 | Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase. | J Biol Chem | 1994 Sep 23 |
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| 15 | 7523381 | The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. | J Biol Chem | 1994 Oct 7 |
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| 16 | 7525306 | B cell antigen receptor cross-linking induces tyrosine phosphorylation and membrane translocation of a multimeric Shc complex that is augmented by CD19 co-ligation. | Eur J Immunol | 1994 Nov |
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| 17 | 7527043 | Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells. | J Biol Chem | 1994 Dec 9 |
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| 18 | 7527391 | Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2. | J Biol Chem | 1994 Dec 16 |
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| 19 | 7529874 | Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS. | Mol Cell Biol | 1995 Feb |
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| 20 | 7537212 | Dynamin GTPase is stimulated by crosslinking through the C-terminal proline-rich domain. | EMBO J | 1995 Apr 3 |
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| 21 | 7537265 | Functional interaction between c-Src and its mitotic target, Sam 68. | J Biol Chem | 1995 Apr 28 |
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| 22 | 7537740 | The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells. | J Biol Chem | 1995 May 5 |
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| 23 | 7539782 | Tyrosine phosphorylation of the proto-oncogene product Vav and its association with the adapter Grb2/Ash in a human leukemia cell line UT-7. | Jpn J Cancer Res | 1995 Apr |
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| 24 | 7539794 | A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor zeta chain tyrosine-based activation motif. | J Biol Chem | 1995 Jun 9 |
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| 25 | 7541031 | Epidermal growth factor-induced association of the SHPTP2 protein tyrosine phosphatase with a 115-kDa phosphotyrosine protein. | J Biol Chem | 1995 Jun 23 |
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| 26 | 7549895 | Signal transduction through the IL-4 and insulin receptor families. | Stem Cells | 1995 Jul |
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| 27 | 7559490 | Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells. | J Biol Chem | 1995 Oct 6 |
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| 28 | 7561087 | Modulation of the Grb2-associated protein complex in human CD4+ T cells by receptor activation. | J Immunol | 1995 Oct 15 |
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| 29 | 7566970 | Quantitative analysis of Grb2-Sos1 interaction: the N-terminal SH3 domain of Grb2 mediates affinity. | Oncogene | 1995 Sep 21 |
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| 30 | 7568038 | p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. | Proc Natl Acad Sci U S A | 1995 Sep 12 |
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| 31 | 7592693 | Coupling of the proto-oncogene product c-Cbl to the epidermal growth factor receptor. | J Biol Chem | 1995 Oct 27 |
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| 32 | 7597091 | Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin. | Proc Natl Acad Sci U S A | 1995 Jun 20 |
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| 33 | 7608150 | Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless. | J Biol Chem | 1995 Jul 7 |
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| 34 | 7629138 | Differential interactions of human Sos1 and Sos2 with Grb2. | J Biol Chem | 1995 Aug 4 |
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| 35 | 7629168 | Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR. | J Biol Chem | 1995 Aug 4 |
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| 36 | 7641883 | The Grb2 adaptor. | FEBS Lett | 1995 Aug 1 |
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| 37 | 7642542 | Ionizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinase. | J Biol Chem | 1995 Aug 11 |
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| 38 | 7651538 | Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. | Nature | 1995 Aug 31 |
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| 39 | 7664271 | Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. | Cancer Res | 1995 Sep 15 |
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| 40 | 7673108 | Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex. | J Biol Chem | 1995 Sep 8 |
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| 41 | 7691810 | Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells. | J Biol Chem | 1993 Oct 15 |
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| 42 | 7716522 | Crystal structure of the mammalian Grb2 adaptor. | Science | 1995 Apr 14 |
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| 43 | 7717978 | The membrane immunoglobulin receptor utilizes a Shc/Grb2/hSOS complex for activation of the mitogen-activated protein kinase cascade in a B-cell line. | Biochem J | 1995 Apr 1 |
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| 44 | 7731718 | The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein. | Oncogene | 1995 Apr 20 |
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| 45 | 7737969 | Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes. | J Biol Chem | 1995 May 5 |
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| 46 | 7752246 | The crystal structure of the N-terminal SH3 domain of Grb2. | J Mol Biol | 1995 May 12 |
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| 47 | 7759503 | Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells. | J Biol Chem | 1995 May 26 |
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| 48 | 7773779 | NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos. | Nat Struct Biol | 1994 Dec |
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| 49 | 7791764 | Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells. | Mol Cell Biol | 1995 Jul |
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| 50 | 7795229 | Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets. | Blood | 1995 Jul 1 |
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