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| 2 | 25686105 | A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. | Nat Med | 2015 Mar |
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| 3 | 26173988 | NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. | Eur J Immunol | 2015 Oct |
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| 4 | 27283237 | Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition. | Sci Rep | 2016 Jun 10 |
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| 5 | 27432019 | The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction. | Eur Heart J | 2017 Mar 14 |
2 |
| 6 | 27730320 | Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy. | Inflammation | 2017 Feb |
2 |
| 7 | 27913620 | PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome. | J Biol Chem | 2017 Jan 20 |
2 |
| 8 | 27994733 | Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950. | ACS Med Chem Lett | 2016 Dec 8 |
1 |
| 9 | 28167322 | NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. | J Hepatol | 2017 May |
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| 10 | 28216285 | A novel mechanism of diabetic vascular endothelial dysfunction: Hypoadiponectinemia-induced NLRP3 inflammasome activation. | Biochim Biophys Acta Mol Basis Dis | 2017 Jun |
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| 11 | 28544564 | Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis. | Arthritis Rheumatol | 2017 Aug |
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| 12 | 28596375 | NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report. | Arterioscler Thromb Vasc Biol | 2017 Aug |
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| 13 | 28726778 | Protection of Mcc950 against high-glucose-induced human retinal endothelial cell dysfunction. | Cell Death Dis | 2017 Jul 20 |
14 |
| 14 | 28761045 | Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis. | Sci Rep | 2017 Jul 31 |
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| 15 | 28848230 | Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. | Nat Microbiol | 2017 Oct |
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| 16 | 28865486 | NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma. | J Exp Clin Cancer Res | 2017 Sep 2 |
4 |
| 17 | 28986310 | The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation. | Biochim Biophys Acta Mol Basis Dis | 2018 Jan |
4 |
| 18 | 29183866 | An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes. | Clin Immunol | 2018 Jun |
4 |
| 19 | 29212744 | Selective NLRP3 (Pyrin Domain-Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage. | Stroke | 2018 Jan |
2 |
| 20 | 29295651 | MCC950, the Selective Inhibitor of Nucleotide Oligomerization Domain-Like Receptor Protein-3 Inflammasome, Protects Mice against Traumatic Brain Injury. | J Neurotrauma | 2018 Jun 1 |
1 |
| 21 | 29507526 | Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway. | Mediators Inflamm | 2018 |
1 |
| 22 | 29594175 | Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis. | ERJ Open Res | 2018 Jan |
1 |
| 23 | 29654318 | Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke. | Sci Rep | 2018 Apr 13 |
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| 24 | 29802206 | Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. | Circulation | 2018 Nov 13 |
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| 25 | 29853850 | Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice. | Neural Plast | 2018 |
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| 26 | 29859317 | Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury. | Neurobiol Dis | 2018 Sep |
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| 27 | 29872077 | MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice. | Sci Rep | 2018 Jun 5 |
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| 28 | 29954866 | Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria. | Proc Natl Acad Sci U S A | 2018 Jul 10 |
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| 29 | 30107367 | Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-κB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic mice. | Int Immunopharmacol | 2018 Oct |
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| 30 | 30146255 | The selective Nlrp3 inflammasome inhibitor Mcc950 attenuates lung ischemia-reperfusion injury. | Biochem Biophys Res Commun | 2018 Sep 18 |
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| 31 | 30217191 | NLRP3 inflammasome-dependent pyroptosis is proposed to be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment. | J Neuroinflammation | 2018 Sep 14 |
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| 32 | 30276509 | NLRP3/Caspase-1 Pathway-Induced Pyroptosis Mediated Cognitive Deficits in a Mouse Model of Sepsis-Associated Encephalopathy. | Inflammation | 2019 Feb |
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| 33 | 30320900 | Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis. | J Cell Biochem | 2019 Apr |
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| 34 | 30333233 | Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory NLRP3-RXR axis in asthma. | J Biol Chem | 2018 Nov 30 |
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| 35 | 30360489 | The Small Molecule NLRP3 Inflammasome Inhibitor MCC950 Does Not Alter Wound Healing in Obese Mice. | Int J Mol Sci | 2018 Oct 23 |
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| 36 | 30363922 | Sevoflurane Inhibits the Th2 Response and NLRP3 Expression in Murine Allergic Airway Inflammation. | J Immunol Res | 2018 |
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| 37 | 30468127 | NLRP3 Inflammasome Activation Leads to Epileptic Neuronal Apoptosis. | Curr Neurovasc Res | 2018 |
2 |
| 38 | 30524241 | Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice. | Front Cell Neurosci | 2018 |
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| 39 | 30802677 | The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice. | Int Immunopharmacol | 2019 May |
2 |
| 40 | 30818045 | NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia. | Pharmacol Res | 2019 Apr |
2 |
| 41 | 30939192 | NLRP3 inflammasome mediates angiotensin II-induced islet β cell apoptosis. | Acta Biochim Biophys Sin (Shanghai) | 2019 May 23 |
8 |
| 42 | 31002919 | NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice. | Life Sci | 2019 Jun 15 |
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| 43 | 31086329 | MCC950 closes the active conformation of NLRP3 to an inactive state. | Nat Chem Biol | 2019 Jun |
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| 44 | 31170267 | An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS). | PLoS Pathog | 2019 Jun |
2 |
| 45 | 31239738 | Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis. | Diabetes Metab Syndr Obes | 2019 |
2 |
| 46 | 31320730 | NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology. | Cell Mol Immunol | 2020 Mar |
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| 47 | 31332667 | Induction of Neuroinflammation and Neurotoxicity by Synthetic Hemozoin. | Cell Mol Neurobiol | 2019 Nov |
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| 48 | 31447572 | A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation. | Diabetes Metab Syndr Obes | 2019 |
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| 49 | 31521245 | Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis. | Biochem Biophys Res Commun | 2019 Nov 5 |
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| 50 | 32087497 | Inhibiting NLRP3 inflammasome with MCC950 ameliorates perioperative neurocognitive disorders, suppressing neuroinflammation in the hippocampus in aged mice. | Int Immunopharmacol | 2020 Feb 19 |
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