6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one






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1 19720143 Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts. Cell Signal 2009 Dec 1
2 20354780 Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells. Breast Cancer Res Treat 2011 Feb 2
3 21212402 Oxidative stress-induced degradation of thioredoxin-1 and apoptosis is inhibited by thioredoxin-1-actin interaction in endothelial cells. Arterioscler Thromb Vasc Biol 2011 Mar 1
4 21401419 Effect of focal adhesion kinase on the regulation of realignment and tenogenic differentiation of human mesenchymal stem cells by mechanical stretch. Connect Tissue Res 2011 Oct 3
5 21775609 Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells. J Neurosci 2011 Jul 20 2
6 21898412 RhoA/ROCK, cytoskeletal dynamics, and focal adhesion kinase are required for mechanical stretch-induced tenogenic differentiation of human mesenchymal stem cells. J Cell Physiol 2012 Jun 1
7 21925512 Evidence for activation of BK Ca channels by a known inhibitor of focal adhesion kinase, PF573228. Life Sci 2011 Nov 7 2
8 22069492 Stanniocalcin-1 regulates re-epithelialization in human keratinocytes. PLoS One 2011 2
9 22227408 Hyaluronic acid influence on platelet-induced airway smooth muscle cell proliferation. Exp Cell Res 2012 Mar 10 1
10 22900166 Contractile Activity Regulates Inducible Nitric Oxide Synthase Expression and NO(i) Production in Cardiomyocytes via a FAK-Dependent Signaling Pathway. J Signal Transduct 2012 2
11 22914642 Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts. Am J Physiol Cell Physiol 2012 Nov 1 4
12 23238518 Integrin-substrate interactions underlying shear-induced inhibition of the inflammatory response of endothelial cells. Thromb Haemost 2013 Feb 1
13 23988606 CCN2 promotes keratinocyte adhesion and migration via integrin α5β1. Exp Cell Res 2013 Nov 15 1
14 24063814 Cyr61 induces the expression of monocyte chemoattractant protein-1 via the integrin ανβ3, FAK, PI3K/Akt, and NF-κB pathways in retinal vascular endothelial cells. Cell Signal 2014 Jan 4
15 24260297 Periostin links mechanical strain to inflammation in abdominal aortic aneurysm. PLoS One 2013 2
16 24331979 Role of p38, ERK1/2, focal adhesion kinase, RhoA/ROCK and cytoskeleton in the adipogenesis of human mesenchymal stem cells. J Biosci Bioeng 2014 May 1
17 24365239 Activation of focal adhesion kinase via M1 muscarinic acetylcholine receptor is required in restitution of intestinal barrier function after epithelial injury. Biochim Biophys Acta 2014 Apr 1
18 25056351 Inhibition of smooth muscle force generation by focal adhesion kinase inhibitors in the hyperplastic human prostate. Am J Physiol Renal Physiol 2014 Oct 1 1
19 25409876 Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer 2014 Nov 20 9
20 25447223 Angiopoietin-1 blocks neurotoxic zinc entry into cortical cells via PIP2 hydrolysis-mediated ion channel inhibition. Neurobiol Dis 2015 Sep 4
21 25633387 Cyclic mechanical stretching promotes migration but inhibits invasion of rat bone marrow stromal cells. Stem Cell Res 2015 Mar 1
22 25660453 The involvement of FAK-PI3K-AKT-Rac1 pathway in porcine reproductive and respiratory syndrome virus entry. Biochem Biophys Res Commun 2015 Mar 6 3
23 25663277 Involvement of nucleotides in glial growth following scratch injury in avian retinal cell monolayer cultures. Purinergic Signal 2015 Jun 1
24 26001294 p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling. Oncotarget 2017 Mar 7 3
25 26319373 Cellular fibronectin 1 promotes VEGF-C expression, lymphangiogenesis and lymph node metastasis associated with human oral squamous cell carcinoma. Clin Exp Metastasis 2015 Oct 2
26 26443539 Overexpression of Rab5a promotes hepatocellular carcinoma cell proliferation and invasion via FAK signaling pathway. Tumour Biol 2016 Mar 3
27 26890302 Regulation of BMP2-induced intracellular calcium increases in osteoblasts. J Orthop Res 2016 Oct 2
28 27127174 Focal adhesion kinase and paxillin promote migration and adhesion to fibronectin by swine skeletal muscle satellite cells. Oncotarget 2016 May 24 1
29 27154636 Rap2B promotes cell proliferation, migration and invasion in prostate cancer. Med Oncol 2016 Jun 3
30 27497669 LEFTY2 Controls Migration of Human Endometrial Cancer Cells via Focal Adhesion Kinase Activity (FAK) and miRNA-200a. Cell Physiol Biochem 2016 2
31 27856749 In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway. Proc Natl Acad Sci U S A 2016 Nov 29 4
32 28011582 Fluid shear stress induces upregulation of COX-2 and PGI<sub>2</sub> release in endothelial cells via a pathway involving PECAM-1, PI3K, FAK, and p38. Am J Physiol Heart Circ Physiol 2017 Mar 1 2
33 28067275 SDF-1/CXCR4 axis induces human dental pulp stem cell migration through FAK/PI3K/Akt and GSK3β/β-catenin pathways. Sci Rep 2017 Jan 9 1
34 28259988 Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro. Int J Oncol 2017 Apr 2
35 28459212 Focal adhesion kinase inhibitor PF573228 and death receptor 5 agonist lexatumumab synergistically induce apoptosis in pancreatic carcinoma. Tumour Biol 2017 May 4
36 28733702 Anti-invasive effects of CXCR4 and FAK inhibitors in non-small cell lung carcinomas with mutually inactivated p53 and PTEN tumor suppressors. Invest New Drugs 2017 Dec 1
37 28818394 Focal adhesion kinase family is involved in matrix contraction by transdifferentiated Müller cells. Exp Eye Res 2017 Nov 8
38 29090460 FAK inhibitors induce cell multinucleation and dramatically increase pro-tumoral cytokine expression in RAW 264.7 macrophages. FEBS Lett 2017 Dec 2
39 29190494 FUS-CHOP Promotes Invasion in Myxoid Liposarcoma through a SRC/FAK/RHO/ROCK-Dependent Pathway. Neoplasia 2018 Jan 3
40 29678550 Low-level shear stress promotes migration of liver cancer stem cells via the FAK-ERK1/2 signalling pathway. Cancer Lett 2018 Jul 28 2
41 30756417 CTGF induces tenogenic differentiation and proliferation of adipose-derived stromal cells. J Orthop Res 2019 Mar 3
42 30761269 Inhibition of FAK Signaling Elicits Lamin A/C-Associated Nuclear Deformity and Cellular Senescence. Front Oncol 2019 1
43 30977220 Fibronectin promotes cervical cancer tumorigenesis through activating FAK signaling pathway. J Cell Biochem 2019 Apr 11 3
44 31267530 Vascular endothelial growth factor A/Vascular endothelial growth factor receptor 2 axis promotes human dental pulp stem cell migration via the FAK/PI3K/Akt and p38 MAPK signalling pathways. Int Endod J 2019 Dec 1
45 31297342 Depletion of Host Cell Focal Adhesion Kinase Increases the Susceptibility to Invasion by <i>Trypanosoma cruzi</i> Metacyclic Forms. Front Cell Infect Microbiol 2019 2
46 31468983 Low intensity pulsed ultrasound promotes the migration of bone marrow- derived mesenchymal stem cells via activating FAK-ERK1/2 signalling pathway. Artif Cells Nanomed Biotechnol 2019 Dec 1
47 31556111 Focal adhesion kinase regulates tractional collagen remodeling, matrix metalloproteinase expression, and collagen structure, which in turn affects matrix-induced signaling. J Cell Physiol 2020 Mar 1
48 31604999 Small molecule FAK activator promotes human intestinal epithelial monolayer wound closure and mouse ulcer healing. Sci Rep 2019 Oct 11 1
49 31619255 Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity. Part Fibre Toxicol 2019 Oct 16 3
50 31838119 Increased intracellular Cl<sup>-</sup> concentration by activating FAK promotes airway epithelial BEAS-2B cells proliferation and wound healing. Arch Biochem Biophys 2020 Feb 15 1