gimeracil






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1 9021668 [Mutagenicity study of a new antineoplastic agent S-1, and its components, CDHP, and Oxo]. J Toxicol Sci 1996 Nov 2
2 9140762 Determination of S-1 (combined drug of tegafur, 5-chloro-2,4-dihydroxypyridine and potassium oxonate) and 5-fluorouracil in human plasma and urine using high-performance liquid chromatography and gas chromatography-negative ion chemical ionization mass spectrometry. J Chromatogr B Biomed Sci Appl 1997 Mar 28 2
3 10363584 Therapeutic effect of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) on liver metastasis of xenotransplanted human colon carcinoma. Jpn J Cancer Res 1999 Apr 3
4 10473078 Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor drug. Clin Cancer Res 1999 Aug 2
5 10545788 An early phase II study of oral S-1, a newly developed 5-fluorouracil derivative for advanced and recurrent gastrointestinal cancers. The S-1 Gastrointestinal Cancer Study Group. Oncology 1999 Oct 1
6 10901361 Phase II study of S-1, a novel oral fluorophyrimidine derivative, in patients with metastatic colorectal carcinoma. S-1 Cooperative Colorectal Carcinoma Study Group. Br J Cancer 2000 Jul 1
7 11290431 The significance of dihydropyrimidine dehydrogenase (DPD) activity in bladder cancer. Eur J Cancer 2001 Mar 2
8 11497250 Possible regulation of 5-fluorouracil-induced neuro- and oral toxicities by two biochemical modulators consisting of S-1, a new oral formulation of 5-fluorouracil. Anticancer Res 2001 May-Jun 2
9 12044515 Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells. Eur J Cancer 2002 Jun 11
10 12111108 Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor agent in animal model and in patients with impaired renal function. Cancer Chemother Pharmacol 2002 Jul 4
11 12538461 Phase I study with pharmacokinetics of S-1 on an oral daily schedule for 28 days in patients with solid tumors. Clin Cancer Res 2003 Jan 1
12 12739060 Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors. Cancer Chemother Pharmacol 2003 Jul 4
13 12751387 Significance of dihydropyrimidine dehydrogenase activity in renal cell carcinoma. Eur J Cancer 2003 Mar 2
14 12763215 Phase II trial with S-1 in chemotherapy-naïve patients with gastric cancer. A trial performed by the EORTC Early Clinical Studies Group (ECSG). Eur J Cancer 2003 Jun 2
15 12775012 S-1 in gastric cancer: a comprehensive review. Gastric Cancer 2003 6
16 12853891 Effect of combination of TS-1 and low-dose cisplatin on sarcoma-180 mouse sarcoma. Anticancer Drugs 2003 Jul 1
17 14551502 Dihydropyrimidine dehydrogenase inhibition as a strategy for the oral administration of 5-fluorouracil: utility in the treatment of advanced colorectal cancer. Anticancer Drugs 2003 Oct 1
18 14650374 Comparison of the pharmacokinetics of S-1, an oral anticancer agent, in Western and Japanese patients. J Pharmacokinet Pharmacodyn 2003 Aug 1
19 15075664 The modulated oral fluoropyrimidine prodrug S-1, and its use in gastrointestinal cancer and other solid tumors. Anticancer Drugs 2004 Feb 3
20 15160338 Phase II study of oral S-1 for treatment of metastatic colorectal carcinoma. Cancer 2004 Jun 1 1
21 15331922 Safety and efficacy of S-1, a novel oral fluorouracil antitumor drug, for a chronic renal failure patient maintained on hemodialysis. Oncology 2004 2
22 15550867 A phase II study of S-1 in patients with metastatic breast cancer--a Japanese trial by the S-1 Cooperative Study Group, Breast Cancer Working Group. Breast Cancer 2004 1
23 15949589 Role of dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine against non-small cell lung cancer--in correlation with the tumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase. Lung Cancer 2005 Jul 3
24 15993511 The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5-fluorouracil in human lung cancer cells. Lung Cancer 2005 Sep 3
25 16315929 [A trial of TS-1 administration on the basis of the pharmacokinetic study for an advanced gastric cancer patient with impaired renal function]. Gan To Kagaku Ryoho 2005 Oct 4
26 16317557 Potassium oxonate, an enzyme inhibitor compounded in S-1, reduces the suppression of antitumor immunity induced by 5-fluorouracil. Cancer Chemother Pharmacol 2006 Aug 1
27 16549996 Effect of gastrectomy on the pharmacokinetics of 5-fluorouracil and gimeracil after oral administration of S-1. Anticancer Drugs 2006 Apr 1
28 16897967 [Timeline from discovery of 5-FU to development of an oral anticancer agent S-1 and its drug concept]. Gan To Kagaku Ryoho 2006 Jun 1
29 16897969 [Pharmacokinetics of S-1]. Gan To Kagaku Ryoho 2006 Jun 2
30 16897986 [S-1 as a single agent for colorectal cancer]. Gan To Kagaku Ryoho 2006 Jun 1
31 16898001 [Combination chemotherapy with S-1 and cisplatin for non-small cell lung cancer]. Gan To Kagaku Ryoho 2006 Jun 1
32 17092280 The significance of the expression of dihydropyrimidine dehydrogenase in prostate cancer. BJU Int 2007 Mar 2
33 17603216 Development of a pharmacokinetic model to optimize the dosage regimen of TS-1, a combination preparation of tegafur, gimeracil and oteracil potassium. Drug Metab Pharmacokinet 2007 Jun 3
34 17699726 Alteration of dihydropyrimidine dehydrogenase expression by IFN-alpha affects the antiproliferative effects of 5-fluorouracil in human hepatocellular carcinoma cells. Mol Cancer Ther 2007 Aug 6
35 17708166 Consumer-directed health plans: what happened? Healthc Financ Manage 2007 Aug 1
36 17940834 Synergistic antitumor effect of combined 5-fluorouracil (5-FU) with 5-chloro-2,4-dihydroxypyridine on 5-FU-resistant gastric cancer cells: possible role of a dihydropyrimidine dehydrogenase-independent mechanism. J Gastroenterol 2007 Oct 1
37 17982671 Epigenetic regulation of chemosensitivity to 5-fluorouracil and cisplatin by zebularine in oral squamous cell carcinoma. Int J Oncol 2007 Dec 2
38 18172246 Can inhibiting dihydropyrimidine dehydrogenase limit hand-foot syndrome caused by fluoropyrimidines? Clin Cancer Res 2008 Jan 1 2
39 18309485 High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1. Cancer Chemother Pharmacol 2008 Dec 2
40 18799915 [Case report of gastric cancer patient who suffered life-threatening adverse events including severe myelosuppression during neoadjuvant chemotherapy with S-1 and CDDP combination]. Gan To Kagaku Ryoho 2008 Sep 3
41 19052037 Development history and concept of an oral anticancer agent S-1 (TS-1): its clinical usefulness and future vistas. Jpn J Clin Oncol 2009 Jan 1
42 19093184 Successful treatment of advanced gallbladder cancer with an anticancer drug S-1: assessment based on intratumoral gene. Int J Clin Oncol 2008 Dec 2
43 19243284 S-1: a promising new oral fluoropyrimidine derivative. Expert Opin Investig Drugs 2009 Mar 1
44 19632949 S-1: a new oral fluoropyrimidine in the treatment of patients with advanced non-small-cell lung cancer. Clin Lung Cancer 2009 Jul 1
45 19724848 S-1 mediates the inhibition of lymph node metastasis in oral cancer cells. Oncol Rep 2009 Oct 4
46 19822965 Simultaneous determination of tegafur and gimeracil in human plasma by liquid chromatography/tandem mass spectrometry. Anal Sci 2009 Oct 1
47 19921195 Can the 2-(13)C-uracil breath test be used to predict the effect of the antitumor drug S-1? Cancer Chemother Pharmacol 2010 Jul 1
48 20559897 Phase 1/2 clinical study of irinotecan and oral S-1 (IRIS) in patients with advanced gastric cancer. Adv Ther 2010 Jul 1
49 21378348 A phase I study evaluating the effect of CDHP as a component of S-1 on the pharmacokinetics of 5-fluorouracil. Anticancer Res 2011 Feb 5
50 21487460 Transient effectiveness of an oral 5-Fluorouracil derivative, s-1, for epirubicin, cyclophosphamide and Paclitaxel refractory skin metastases from possible occult breast cancer in a male. Case Rep Dermatol 2011 Feb 23 1