| 1 | 9296363 | Tryptanthrins: a novel class of agonists of the aryl hydrocarbon receptor. | Biochem Pharmacol | 1997 Jul 1 |
3 |
| 2 | 10721082 | Tryptanthrins and other tryptophan-derived agonists of the dioxin receptor. | Adv Exp Med Biol | 1999 |
1 |
| 3 | 11050308 | Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages. | Eur J Pharmacol | 2000 Oct 27 |
2 |
| 4 | 11422788 | Cell differentiation and apoptosis of monocytic and promyelocytic leukemia cells (U-937 and HL-60) by tryptanthrin, an active ingredient of Polygonum tinctorium Lour. | Pathol Int | 2001 May |
3 |
| 5 | 11488453 | Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria. | Planta Med | 2001 Jul |
2 |
| 6 | 11848486 | Prevention of azoxymethane-induced intestinal tumors by a crude ethyl acetate-extract and tryptanthrin extracted from Polygonum tinctorium Lour. | Anticancer Res | 2001 Sep-Oct |
1 |
| 7 | 12391548 | Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis. | Planta Med | 2002 Oct |
1 |
| 8 | 12612449 | Tryptanthrin inhibits interferon-gamma production by Peyer's patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin. | Biol Pharm Bull | 2003 Mar |
6 |
| 9 | 15684480 | Inhibition of hepatocyte growth factor induction in human dermal fibroblasts by tryptanthrin. | Biol Pharm Bull | 2005 Feb |
8 |
| 10 | 17482571 | Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells. | Biochem Biophys Res Commun | 2007 Jun 22 |
10 |
| 11 | 19318911 | Downregulation of GSTpi expression by tryptanthrin contributing to sensitization of doxorubicin-resistant MCF-7 cells through c-jun NH2-terminal kinase-mediated apoptosis. | Anticancer Drugs | 2009 Jun |
4 |
| 12 | 19559779 | Anti-inflammatory effects of the extract of indigo naturalis in human neutrophils. | J Ethnopharmacol | 2009 Aug 17 |
1 |
| 13 | 21216280 | Tryptanthrin inhibits Th2 development, and IgE-mediated degranulation and IL-4 production by rat basophilic leukemia RBL-2H3 cells. | J Ethnopharmacol | 2011 Mar 24 |
11 |
| 14 | 21747710 | Proliferation-attenuating and apoptosis-inducing effects of tryptanthrin on human chronic myeloid leukemia K562 cell line in vitro. | Int J Mol Sci | 2011 |
4 |
| 15 | 21797843 | On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo. | Br J Pharmacol | 2012 Feb |
1 |
| 16 | 21824448 | Transport characteristics of tryptanthrin and its inhibitory effect on P-gp and MRP2 in Caco-2 cells. | J Pharm Pharm Sci | 2011 |
10 |
| 17 | 23352980 | PIM1 kinase inhibitors induce radiosensitization in non-small cell lung cancer cells. | Pharmacol Res | 2013 Apr |
2 |
| 18 | 23500671 | Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells. | Chem Biol Interact | 2013 Apr 25 |
3 |
| 19 | 23543631 | Progress in the studies on tryptanthrin, an alkaloid of history. | Arch Pharm Res | 2013 May |
1 |
| 20 | 24099220 | Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. | J Med Chem | 2013 Nov 14 |
1 |
| 21 | 24295961 | Tryptanthrin ameliorates atopic dermatitis through down-regulation of TSLP. | Arch Biochem Biophys | 2014 Jan 15 |
2 |
| 22 | 24358167 | Tryptanthrin inhibits angiogenesis by targeting the VEGFR2-mediated ERK1/2 signalling pathway. | PLoS One | 2013 |
13 |
| 23 | 25210977 | A pressure-tolerant polymer microfluidic device fabricated by the simultaneous solidification-bonding method and flash chemistry application. | Lab Chip | 2014 Nov 7 |
1 |
| 24 | 25273386 | Tryptanthrin protects hepatocytes against oxidative stress via activation of the extracellular signal-regulated kinase/NF-E2-related factor 2 pathway. | Biol Pharm Bull | 2014 |
14 |
| 25 | 25383546 | The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells. | PLoS One | 2014 |
2 |
| 26 | 25809558 | Benzo[b]tryptanthrin inhibits MDR1, topoisomerase activity, and reverses adriamycin resistance in breast cancer cells. | ChemMedChem | 2015 May |
2 |
| 27 | 26341616 | Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting Akt and FAK signaling in human vascular endothelial cells. | J Ethnopharmacol | 2015 Nov 4 |
10 |
| 28 | 27044814 | Tryptanthrin reduces mast cell proliferation promoted by TSLP through modulation of MDM2 and p53. | Biomed Pharmacother | 2016 Apr |
4 |
| 29 | 27093249 | Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin. | Planta Med | 2016 Jul |
1 |
| 30 | 27420350 | Caco-2 Permeability Studies and In Vitro hERG Liability Assessment of Tryptanthrin and Indolinone. | Planta Med | 2016 Aug |
1 |
| 31 | 27475108 | Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. | Eur J Med Chem | 2016 Nov 10 |
4 |
| 32 | 27698647 | Novel Fe<sup>II</sup> and Co<sup>II</sup> Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA. | Bioinorg Chem Appl | 2016 |
2 |
| 33 | 28093031 | The inhibitory effects of five alkaloids on the substrate transport mediated through human organic anion and cation transporters. | Xenobiotica | 2018 Feb |
4 |
| 34 | 28210215 | Tryptanthrin Suppresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling. | Front Cell Neurosci | 2017 |
6 |
| 35 | 28828587 | Tryptanthrin prevents oxidative stress-mediated apoptosis through AMP-activated protein kinase-dependent p38 mitogen-activated protein kinase activation. | Arch Pharm Res | 2017 Sep |
13 |
| 36 | 28865459 | Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis. | BMC Complement Altern Med | 2017 Sep 2 |
1 |
| 37 | 29532413 | Anti-neuroinflammatory effects of tryptanthrin from Polygonum tinctorium Lour. in lipopolysaccharide-stimulated BV2 microglial cells. | Arch Pharm Res | 2018 Apr |
12 |
| 38 | 29724065 | Tryptanthrin Protects Mice against Dextran Sulfate Sodium-Induced Colitis through Inhibition of TNF-α/NF-κB and IL-6/STAT3 Pathways. | Molecules | 2018 May 2 |
3 |
| 39 | 30321802 | Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives. | Eur J Med Chem | 2018 Dec 5 |
3 |
| 40 | 30347329 | Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors. | Eur J Med Chem | 2019 Jan 1 |
1 |
| 41 | 30852259 | Indole alkaloids indigodoles A-C from aerial parts of Strobilanthes cusia in the traditional Chinese medicine Qing Dai have anti-IL-17 properties. | Phytochemistry | 2019 Jun |
1 |
| 42 | 31005035 | The anti-angiogenic effect of tryptanthrin is mediated by the inhibition of apelin promoter activity and shortened mRNA half-life in human vascular endothelial cells. | Phytomedicine | 2019 May |
10 |
| 43 | 31549585 | Nano-encapsulated tryptanthrin derivative for combined anticancer therapy via inhibiting indoleamine 2,3-dioxygenase and inducing immunogenic cell death. | Nanomedicine (Lond) | 2019 Sep |
1 |
| 44 | 31580660 | <i>N</i>-Benzyl/Aryl Substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase. | J Med Chem | 2019 Oct 24 |
4 |
| 45 | 31647221 | A Biomimetic, One-Step Transformation of Simple Indolic Compounds to <i>Malassezia</i>-Related Alkaloids with High AhR Potency and Efficacy. | Chem Res Toxicol | 2019 Nov 18 |
1 |
| 46 | 31663659 | Pre-clinical evidences for the efficacy of tryptanthrin as a potent suppressor of skin cancer. | Cell Prolif | 2020 Jan |
5 |
| 47 | 32173427 | The anti-TH17 polarization effect of Indigo naturalis and tryptanthrin by differentially inhibiting cytokine expression. | J Ethnopharmacol | 2020 Jun 12 |
4 |
| 48 | 32247733 | Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase. | Bioorg Med Chem Lett | 2020 Jun 1 |
6 |
| 49 | 32792961 | Therapeutic Effects of Tryptanthrin and Tryptanthrin-6-Oxime in Models of Rheumatoid Arthritis. | Front Pharmacol | 2020 |
19 |
| 50 | 33151167 | Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment. | Acta Pharm | 2021 Jun 1 |
9 |