1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine






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1 22512618 Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem 2012 May 10 1
2 26165074 [Vonoprazan: a novel potassium-competitive acid blocker]. Nihon Rinsho 2015 Jul 2
3 26369775 The First-in-Class Potassium-Competitive Acid Blocker, Vonoprazan Fumarate: Pharmacokinetic and Pharmacodynamic Considerations. Clin Pharmacokinet 2016 Apr 6
4 26559637 Randomised clinical trial: vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the healing of erosive oesophagitis. Aliment Pharmacol Ther 2016 Jan 1
5 26991399 Potent acid inhibition by vonoprazan in comparison with esomeprazole, with reference to CYP2C19 genotype. Aliment Pharmacol Ther 2016 May 2
6 27414183 In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica 2017 Dec 10
7 27465369 Lansoprazole Exacerbates Pemetrexed-Mediated Hematologic Toxicity by Competitive Inhibition of Renal Basolateral Human Organic Anion Transporter 3. Drug Metab Dispos 2016 Oct 1
8 27891632 Randomised clinical trial: efficacy and safety of vonoprazan vs. lansoprazole in patients with gastric or duodenal ulcers - results from two phase 3, non-inferiority randomised controlled trials. Aliment Pharmacol Ther 2017 Jan 1
9 27928738 Effect of Multiple Oral Doses of the Potent CYP3A4 Inhibitor Clarithromycin on the Pharmacokinetics of a Single Oral Dose of Vonoprazan: A Phase I, Open-Label, Sequential Design Study. Clin Drug Investig 2017 Mar 2
10 28190016 Efficacy of Vonoprazan for Proton Pump Inhibitor-Resistant Reflux Esophagitis. Digestion 2017 3
11 28875498 Comparative Study of Effects of Vonoprazan and Esomeprazole on Antiplatelet Function of Clopidogrel or Prasugrel in Relation to CYP2C19 Genotype. Clin Pharmacol Ther 2018 May 3
12 28986609 Comparison of effect of an increased dosage of vonoprazan versus vonoprazan plus lafutidine on gastric acid inhibition and serum gastrin. Eur J Clin Pharmacol 2018 Jan 1
13 29057719 Changes in gefitinib, erlotinib and osimertinib pharmacokinetics under various gastric pH levels following oral administration of omeprazole and vonoprazan in rats. Xenobiotica 2018 Nov 1
14 29393198 Does the Novel Potassium-Competitive Acid Blocker Vonoprazan Cause More Hypergastrinemia than Conventional Proton Pump Inhibitors? A Multicenter Prospective Cross-Sectional Study. Digestion 2018 3
15 30361928 In Vitro Assessment of Potential for CYP-Inhibition-Based Drug-Drug Interaction Between Vonoprazan and Clopidogrel. Eur J Drug Metab Pharmacokinet 2019 Apr 6
16 30562434 Potassium-competitive acid blocker. Nihon Rinsho 2016 Aug 1
17 30755541 Comparison of the Use of Vonoprazan and Proton Pump Inhibitors for the Treatment of Peptic Ulcers Resulting from Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis. Med Sci Monit 2019 Feb 13 1
18 30845361 Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers. Br J Clin Pharmacol 2019 Jul 3
19 30897577 Efficacy of Vonoprazan, a Novel Potassium-Competitive Acid Blocker, in Patients with Proton Pump Inhibitor-Refractory Acid Reflux. Digestion 2020 3
20 30993551 Inhibitory Effect of Vonoprazan on the Metabolism of [<sup>14</sup>C]Prasugrel in Human Liver Microsomes. Eur J Drug Metab Pharmacokinet 2019 Oct 6
21 31178490 Vonoprazan versus Lansoprazole for the Initial Treatment of Reflux Esophagitis: A Cost-effectiveness Analysis in Japan. Intern Med 2019 Sep 1 2
22 31320930 Current status of first- and second-line <i>Helicobacter pylori</i> eradication therapy in the metropolitan area: a multicenter study with a large number of patients. Therap Adv Gastroenterol 2019 1
23 31679094 Risk of hemorrhage and stricture significantly increases in elderly patients with proton pump inhibitor (PPI)-resistant reflux esophagitis. Esophagus 2020 Jan 2
24 32062650 The Ameliorating Effect of Switching to Vonoprazan: A Novel Potassium-Competitive Acid Blocker in Patients with Proton Pump Inhibitor Refractory Non-Erosive Reflux Disease. Digestion 2021 1
25 32116727 Cytochrome P450-Based Drug-Drug Interactions of Vonoprazan <i>In Vitro</i> and <i>In Vivo</i>. Front Pharmacol 2020 4
26 32118778 Vonoprazan vs proton pump inhibitors in treating post-endoscopic submucosal dissection ulcers and preventing bleeding: A meta-analysis of randomized controlled trials and observational studies. Medicine (Baltimore) 2020 Feb 1
27 32993151 Effect of Antibiotic Susceptibility and <i>CYP3A4/5</i> and <i>CYP2C19</i> Genotype on the Outcome of Vonoprazan-Containing <i>Helicobacter pylori</i> Eradication Therapy. Antibiotics (Basel) 2020 Sep 26 6
28 32998241 The Potential Benefits of Vonoprazan as <i>Helicobacter pylori</i> Infection Therapy. Pharmaceuticals (Basel) 2020 Sep 28 2
29 32999170 Effects of Concomitant Administration of Vonoprazan Fumarate on the Tacrolimus Blood Concentration in Kidney Transplant Recipients. Biol Pharm Bull 2020 1
30 33305731 Safety profile of vonoprazan compared with proton pump inhibitors: insight from a pharmacovigilance study. Pharmazie 2020 Oct 1 1
31 33333602 Editorial: "Stardust gastric mucosa" - A novel and consistent marker of vonoprazan safety during follow-up? Aliment Pharmacol Ther 2021 Jan 1
32 33693287 Effects of Vonoprazan on the Antiplatelet Function of Prasugrel Assessed by the VerifyNow P2Y<sub>12</sub> Assay in Patients With Coronary Artery Disease. Circ Rep 2020 Dec 18 2
33 34059932 Effects of pirenzepine on vonoprazan-induced gastric acid inhibition and hypergastrinemia. Eur J Clin Pharmacol 2021 Jul 2
34 34176835 Severe Hypomagnesemia Associated with the Long-term Use of the Potassium-competitive Acid Blocker Vonoprazan. Intern Med 2022 Jan 1 1
35 34484992 Treatment strategies for reflux esophagitis including a potassium-competitive acid blocker: A cost-effectiveness analysis in Japan. J Gen Fam Med 2021 Sep 2
36 34867368 Co-Administration of Vonoprazan, Not Tegoprazan, Affects the Pharmacokinetics of Atorvastatin in Healthy Male Subjects. Front Pharmacol 2021 1
37 35004113 Vonoprazan-associated long QT syndrome. J Gen Fam Med 2022 Jan 1
38 35214161 Novel Cocrystals of Vonoprazan: Machine Learning-Assisted Discovery. Pharmaceutics 2022 Feb 16 2
39 35226174 Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021. J Gastroenterol 2022 Apr 1
40 35386943 Use of vonoprazan, a novel potassium-competitive acid blocker, for the treatment of proton pump inhibitor-refractory reflux esophagitis in patients with systemic sclerosis. J Scleroderma Relat Disord 2022 Feb 4
41 35571388 Cost-effectiveness analysis of vonoprazan versus proton pump inhibitors in the treatment of reflux esophagitis in China. Ann Transl Med 2022 Apr 2