siponimod






33 Article(s)
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1 21729281 Fingolimod modulates microglial activation to augment markers of remyelination. J Neuroinflammation 2011 Jul 5 1
2 23285242 The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat. PLoS One 2012 2
3 23436932 Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3. J Immunol 2013 Apr 1 1
4 26856814 The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. J Neuroinflammation 2016 Feb 8 11
5 27566665 Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis. J Neuroinflammation 2016 Aug 26 2
6 29205338 S1P receptor antagonists fingolimod and siponimod do not improve the outcome of experimental autoimmune myasthenia gravis mice after disease onset. Eur J Immunol 2018 Mar 2
7 29273968 In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics. Eur J Clin Pharmacol 2018 Apr 12
8 29735753 Metabolism and Disposition of Siponimod, a Novel Selective S1P<sub>1</sub>/S1P<sub>5</sub> Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism. Drug Metab Dispos 2018 Jul 3
9 30088221 Effect of Fluconazole Coadministration and CYP2C9 Genetic Polymorphism on Siponimod Pharmacokinetics in Healthy Subjects. Clin Pharmacokinet 2019 Mar 10
10 30105453 Siponimod pharmacokinetics, safety, and tolerability in combination with rifampin, a CYP2C9/3A4 inducer, in healthy subjects. Eur J Clin Pharmacol 2018 Dec 3
11 31144287 Siponimod: First Global Approval. Drugs 2019 Jun 1
12 31199498 Prediction of the Impact of Cytochrome P450 2C9 Genotypes on the Drug-Drug Interaction Potential of Siponimod With Physiologically-Based Pharmacokinetic Modeling: A Comprehensive Approach for Drug Label Recommendations. Clin Pharmacol Ther 2019 Nov 3
13 31392364 Siponimod pharmacokinetics, safety, and tolerability in combination with the potent CYP3A4 inhibitor itraconazole in healthy subjects with different CYP2C9 genotypes. Eur J Clin Pharmacol 2019 Nov 3
14 32322257 Siponimod (BAF312) Activates Nrf2 While Hampering NFκB in Human Astrocytes, and Protects From Astrocyte-Induced Neurodegeneration. Front Immunol 2020 19
15 32487716 A G protein-biased S1P<sub>1</sub> agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers. Sci Signal 2020 Jun 2 3
16 32488676 Siponimod (Mayzent) Downregulates RhoA and Cell Surface Expression of the S1P1 and CX3CR1 Receptors in Mouse RAW 264.7 Macrophages. Arch Immunol Ther Exp (Warsz) 2020 Jun 1 7
17 32801704 Nanoparticle BAF312@CaP-NP Overcomes Sphingosine-1-Phosphate Receptor-1-Mediated Chemoresistance Through Inhibiting S1PR1/P-STAT3 Axis in Ovarian Carcinoma. Int J Nanomedicine 2020 5
18 32810927 A label-free impedance assay in endothelial cells differentiates the activation and desensitization properties of clinical S1P<sub>1</sub> agonists. FEBS Open Bio 2020 Oct 1
19 33058113 Secondary progressive multiple sclerosis - from neuropathology to definition and effective treatment. Neurol Neurochir Pol 2020 1
20 33108633 Siponimod: A Review in Secondary Progressive Multiple Sclerosis. CNS Drugs 2020 Nov 2
21 33577891 Protective effect of the sphingosine-1 phosphate receptor agonist siponimod on disrupted blood brain barrier function. Biochem Pharmacol 2021 Apr 4
22 33797705 Sphingosine 1-Phosphate Receptor Modulators for Multiple Sclerosis. CNS Drugs 2021 Apr 2
23 34059068 The targetable nanoparticle BAF312@cRGD-CaP-NP represses tumor growth and angiogenesis by downregulating the S1PR1/P-STAT3/VEGFA axis in triple-negative breast cancer. J Nanobiotechnology 2021 May 31 18
24 34109627 PharmVar GeneFocus: CYP2C9. Clin Pharmacol Ther 2021 Sep 1
25 34340305 Identification of Potential Inhibitors against Epstein-Barr Virus Nuclear Antigen 1 (EBNA1): An Insight from Docking and Molecular Dynamic Simulations. ACS Chem Neurosci 2021 Aug 18 3
26 34599741 Decreased Astrocytic CCL2 Accounts for BAF-312 Effect on PBMCs Transendothelial Migration Through a Blood Brain Barrier in Vitro Model. J Neuroimmune Pharmacol 2021 Oct 2 1
27 34777855 Siponimod (BAF312) penetrates, distributes, and acts in the central nervous system: Preclinical insights. Mult Scler J Exp Transl Clin 2021 Oct 4
28 34911793 Siponimod Inhibits the Formation of Meningeal Ectopic Lymphoid Tissue in Experimental Autoimmune Encephalomyelitis. Neurol Neuroimmunol Neuroinflamm 2022 Jan 2
29 34937912 Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat Chem Biol 2022 Mar 3
30 35136060 Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun 2022 Feb 8 1
31 35354603 Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models. Neurol Neuroimmunol Neuroinflamm 2022 May 1
32 35426132 The Impact of CYP2C9*11 Allelic Variant on the Pharmacokinetics of Phenytoin and (S)-Warfarin. Clin Pharmacol Ther 2022 Jul 1
33 35620290 Pharmacokinetic Characteristics of Siponimod in Healthy Volunteers and Patients With Multiple Sclerosis: Analyses of Published Clinical Trials. Front Pharmacol 2022 1