1 | 14612543 | FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. | Cancer Res | 2003 Nov 1 |
4 |
2 | 16901503 | Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866. | J Mol Biol | 2006 Sep 8 |
7 |
3 | 17052966 | Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents. | Eur J Med Res | 2006 Aug 30 |
5 |
4 | 17307730 | Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. | J Biol Chem | 2007 Apr 13 |
2 |
5 | 18247435 | Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage. | ChemMedChem | 2008 May |
1 |
6 | 18768589 | Visfatin: a new player in mesangial cell physiology and diabetic nephropathy. | Am J Physiol Renal Physiol | 2008 Nov |
2 |
7 | 18802071 | Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress. | J Immunol | 2008 Oct 1 |
1 |
8 | 18945671 | Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism. | J Biol Chem | 2008 Dec 12 |
3 |
9 | 19286518 | Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. | Science | 2009 May 1 |
1 |
10 | 19426698 | Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo. | Biochem Pharmacol | 2009 May 15 |
1 |
11 | 19533035 | Crystal structure of Rattus norvegicus Visfatin/PBEF/Nampt in complex with an FK866-based inhibitor. | Mol Cells | 2009 Jun 30 |
3 |
12 | 19906834 | Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic beta-cells. | J Mol Endocrinol | 2010 Mar |
6 |
13 | 19936064 | Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE. | PLoS One | 2009 Nov 19 |
6 |
14 | 20558841 | A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity. | Exp Biol Med (Maywood) | 2010 Jul |
4 |
15 | 20608974 | Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages. | FEBS J | 2010 Aug |
2 |
16 | 20647743 | Nampt/PBEF/visfatin and cancer. | Cancer Biol Ther | 2010 Jul 15 |
3 |
17 | 20696207 | Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells. | Exp Hematol | 2010 Nov |
3 |
18 | 20724478 | Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool. | J Biol Chem | 2010 Oct 29 |
2 |
19 | 21246601 | Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway. | Ann Neurol | 2011 Feb |
4 |
20 | 21327328 | Visfatin/PBEF/Nampt induces EMMPRIN and MMP-9 production in macrophages via the NAMPT-MAPK (p38, ERK1/2)-NF-κB signaling pathway. | Int J Mol Med | 2011 Apr |
5 |
21 | 21330015 | Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents. | Eur J Med Chem | 2011 Apr |
2 |
22 | 21492230 | Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas. | APMIS | 2011 Apr |
1 |
23 | 21567435 | A key role for Pre-B cell colony-enhancing factor in experimental hepatitis. | Hepatology | 2011 Aug |
3 |
24 | 21743967 | Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil. | Oncol Rep | 2011 Nov |
7 |
25 | 21812028 | Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: a possible cause for reduced osteogenesis and increased adipogenesis in older individuals. | J Bone Miner Res | 2011 Nov |
1 |
26 | 21975728 | Inhibition of nicotinamide phosphoribosyltransferase modifies LPS-induced inflammatory responses of human monocytes. | Innate Immun | 2012 Jun |
1 |
27 | 22044451 | Pre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models. | J Neurochem | 2012 Jan |
1 |
28 | 22073309 | Visfatin impairs endothelium-dependent relaxation in rat and human mesenteric microvessels through nicotinamide phosphoribosyltransferase activity. | PLoS One | 2011 |
2 |
29 | 22089115 | Nicotinamide phosphoribosyltransferase: a potent therapeutic target in non-small cell lung cancer with epidermal growth factor receptor-gene mutation. | J Thorac Oncol | 2012 Jan |
2 |
30 | 22119381 | Anti-proliferation effect of APO866 on C6 glioblastoma cells by inhibiting nicotinamide phosphoribosyltransferase. | Eur J Pharmacol | 2012 Jan 15 |
4 |
31 | 22319029 | Adipocytes as a source of increased circulating levels of nicotinamide phosphoribosyltransferase/visfatin in active acromegaly. | J Clin Endocrinol Metab | 2012 Apr |
1 |
32 | 22430142 | NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression. | Biochem Biophys Res Commun | 2012 Apr 20 |
7 |
33 | 22452634 | Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction. | Antioxid Redox Signal | 2013 Feb 20 |
3 |
34 | 22490786 | The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. | J Neuroinflammation | 2012 Apr 10 |
10 |
35 | 22728882 | Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells. | Biochem Biophys Res Commun | 2012 Aug 3 |
13 |
36 | 22815158 | Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells. | Int J Cancer | 2013 Feb 15 |
12 |
37 | 22933245 | Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells. | EMBO Mol Med | 2012 Oct |
3 |
38 | 22934941 | Nampt/Visfatin/PBEF: a functionally multi-faceted protein with a pivotal role in malignant tumors. | Curr Pharm Des | 2012 |
1 |
39 | 22955917 | Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition. | Blood | 2012 Oct 25 |
7 |
40 | 23071504 | Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases. | PLoS One | 2012 |
1 |
41 | 23221771 | Intracellular NAD(+) depletion induces autophagic death in multiple myeloma cells. | Autophagy | 2013 Mar |
1 |
42 | 23308217 | [18F]FLT and [18F]FDG PET for non-invasive treatment monitoring of the nicotinamide phosphoribosyltransferase inhibitor APO866 in human xenografts. | PLoS One | 2013 |
1 |
43 | 23435312 | NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity. | Exp Hematol | 2013 Jun |
1 |
44 | 23656769 | [The influence of pre-B-cell colony enhancing factor on adhesive molecule in pulmonary cells in rats with acute lung injury/acute respiratory distress syndrome]. | Zhonghua Wei Zhong Bing Ji Jiu Yi Xue | 2013 Mar |
1 |
45 | 23679915 | Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. | J Med Chem | 2013 Aug 22 |
1 |
46 | 23804809 | Inhibition of pre-B cell colony-enhancing factor (PBEF/NAMPT/visfatin) decreases the ability of human neutrophils to generate reactive oxidants but does not impair bacterial killing. | J Leukoc Biol | 2013 Sep |
1 |
47 | 23831038 | Distinct effects of Nampt inhibition on mild and severe models of lipopolysaccharide-induced myocardial impairment. | Int Immunopharmacol | 2013 Oct |
2 |
48 | 23880765 | CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells. | J Biol Chem | 2013 Sep 6 |
5 |
49 | 23922874 | Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells. | PLoS One | 2013 |
1 |
50 | 23946338 | Nicotinamide phosphoribosyltransferase is required for the calorie restriction-mediated improvements in oxidative stress, mitochondrial biogenesis, and metabolic adaptation. | J Gerontol A Biol Sci Med Sci | 2014 Jan |
6 |