N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide






196 Article(s)
Download
PMID
Title
Journal
Pub. Date
#Total Relationship(s)
1 14612543 FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res 2003 Nov 1 4
2 16901503 Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866. J Mol Biol 2006 Sep 8 7
3 17052966 Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents. Eur J Med Res 2006 Aug 30 5
4 17307730 Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J Biol Chem 2007 Apr 13 2
5 18247435 Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage. ChemMedChem 2008 May 1
6 18768589 Visfatin: a new player in mesangial cell physiology and diabetic nephropathy. Am J Physiol Renal Physiol 2008 Nov 2
7 18802071 Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress. J Immunol 2008 Oct 1 1
8 18945671 Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism. J Biol Chem 2008 Dec 12 3
9 19286518 Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science 2009 May 1 1
10 19426698 Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo. Biochem Pharmacol 2009 May 15 1
11 19533035 Crystal structure of Rattus norvegicus Visfatin/PBEF/Nampt in complex with an FK866-based inhibitor. Mol Cells 2009 Jun 30 3
12 19906834 Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic beta-cells. J Mol Endocrinol 2010 Mar 6
13 19936064 Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE. PLoS One 2009 Nov 19 6
14 20558841 A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity. Exp Biol Med (Maywood) 2010 Jul 4
15 20608974 Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages. FEBS J 2010 Aug 2
16 20647743 Nampt/PBEF/visfatin and cancer. Cancer Biol Ther 2010 Jul 15 3
17 20696207 Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells. Exp Hematol 2010 Nov 3
18 20724478 Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool. J Biol Chem 2010 Oct 29 2
19 21246601 Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway. Ann Neurol 2011 Feb 4
20 21327328 Visfatin/PBEF/Nampt induces EMMPRIN and MMP-9 production in macrophages via the NAMPT-MAPK (p38, ERK1/2)-NF-κB signaling pathway. Int J Mol Med 2011 Apr 5
21 21330015 Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents. Eur J Med Chem 2011 Apr 2
22 21492230 Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas. APMIS 2011 Apr 1
23 21567435 A key role for Pre-B cell colony-enhancing factor in experimental hepatitis. Hepatology 2011 Aug 3
24 21743967 Overexpression of Nampt in gastric cancer and chemopotentiating effects of the Nampt inhibitor FK866 in combination with fluorouracil. Oncol Rep 2011 Nov 7
25 21812028 Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: a possible cause for reduced osteogenesis and increased adipogenesis in older individuals. J Bone Miner Res 2011 Nov 1
26 21975728 Inhibition of nicotinamide phosphoribosyltransferase modifies LPS-induced inflammatory responses of human monocytes. Innate Immun 2012 Jun 1
27 22044451 Pre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models. J Neurochem 2012 Jan 1
28 22073309 Visfatin impairs endothelium-dependent relaxation in rat and human mesenteric microvessels through nicotinamide phosphoribosyltransferase activity. PLoS One 2011 2
29 22089115 Nicotinamide phosphoribosyltransferase: a potent therapeutic target in non-small cell lung cancer with epidermal growth factor receptor-gene mutation. J Thorac Oncol 2012 Jan 2
30 22119381 Anti-proliferation effect of APO866 on C6 glioblastoma cells by inhibiting nicotinamide phosphoribosyltransferase. Eur J Pharmacol 2012 Jan 15 4
31 22319029 Adipocytes as a source of increased circulating levels of nicotinamide phosphoribosyltransferase/visfatin in active acromegaly. J Clin Endocrinol Metab 2012 Apr 1
32 22430142 NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression. Biochem Biophys Res Commun 2012 Apr 20 7
33 22452634 Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction. Antioxid Redox Signal 2013 Feb 20 3
34 22490786 The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Neuroinflammation 2012 Apr 10 10
35 22728882 Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells. Biochem Biophys Res Commun 2012 Aug 3 13
36 22815158 Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells. Int J Cancer 2013 Feb 15 12
37 22933245 Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells. EMBO Mol Med 2012 Oct 3
38 22934941 Nampt/Visfatin/PBEF: a functionally multi-faceted protein with a pivotal role in malignant tumors. Curr Pharm Des 2012 1
39 22955917 Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition. Blood 2012 Oct 25 7
40 23071504 Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases. PLoS One 2012 1
41 23221771 Intracellular NAD(+) depletion induces autophagic death in multiple myeloma cells. Autophagy 2013 Mar 1
42 23308217 [18F]FLT and [18F]FDG PET for non-invasive treatment monitoring of the nicotinamide phosphoribosyltransferase inhibitor APO866 in human xenografts. PLoS One 2013 1
43 23435312 NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity. Exp Hematol 2013 Jun 1
44 23656769 [The influence of pre-B-cell colony enhancing factor on adhesive molecule in pulmonary cells in rats with acute lung injury/acute respiratory distress syndrome]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2013 Mar 1
45 23679915 Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. J Med Chem 2013 Aug 22 1
46 23804809 Inhibition of pre-B cell colony-enhancing factor (PBEF/NAMPT/visfatin) decreases the ability of human neutrophils to generate reactive oxidants but does not impair bacterial killing. J Leukoc Biol 2013 Sep 1
47 23831038 Distinct effects of Nampt inhibition on mild and severe models of lipopolysaccharide-induced myocardial impairment. Int Immunopharmacol 2013 Oct 2
48 23880765 CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells. J Biol Chem 2013 Sep 6 5
49 23922874 Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells. PLoS One 2013 1
50 23946338 Nicotinamide phosphoribosyltransferase is required for the calorie restriction-mediated improvements in oxidative stress, mitochondrial biogenesis, and metabolic adaptation. J Gerontol A Biol Sci Med Sci 2014 Jan 6