Digitoxin






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51 11284449 P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin. Naunyn Schmiedebergs Arch Pharmacol 2001 Mar 2
52 11309248 Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells. Br J Pharmacol 2001 Apr 8
53 11586264 Inhibitory effects of digitalis on the proliferation of androgen dependent and independent prostate cancer cells. J Urol 2001 Nov 1
54 12112021 Progesterone attenuates the inhibitory effects of cardiotonic digitalis on pregnenolone production in rat luteal cells. J Cell Biochem 2002 4
55 15136726 Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells. Proc Natl Acad Sci U S A 2004 May 18 6
56 15249423 Inhibitory effects of digoxin and digitoxin on corticosterone production in rat zona fasciculata-reticularis cells. Br J Pharmacol 2004 Aug 1
57 15554746 Fab antibody fragments: some applications in clinical toxicology. Drug Saf 2004 1
58 15602003 Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells. Mol Pharmacol 2005 Mar 1
59 15983368 Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor. Proc Natl Acad Sci U S A 2005 Jul 5 1
60 16084692 Calcium-dependent regulation of NF-(kappa)B activation in cystic fibrosis airway epithelial cells. Cell Signal 2006 May 2
61 16175571 Mechanisms of digoxin and digitoxin on the production of corticosterone in zona fasciculata-reticularis cells of ovariectomized rats. J Cell Biochem 2006 Feb 1 2
62 16243970 The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proc Natl Acad Sci U S A 2005 Nov 1 1
63 16668240 Multiple forms of plant cytochromes p-450. Plant Physiol 1991 Jul 1
64 16668583 Lidocaine and ATPase inhibitor interaction with the chloroplast envelope. Plant Physiol 1991 Dec 1
65 17095614 Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking. J Pharmacol Exp Ther 2007 Feb 4
66 17338573 De novo approach to 2-deoxy-beta-glycosides: asymmetric syntheses of digoxose and digitoxin. J Org Chem 2007 Mar 30 1
67 18080812 The association of ABCB1 polymorphisms and elevated serum digitoxin concentrations in geriatric patients. Eur J Clin Pharmacol 2008 Apr 5
68 18289081 The de novo synthesis of oligosaccharides: application to the medicinal chemistry SAR-study of digitoxin. Curr Top Med Chem 2008 1
69 18755149 Actein inhibits the Na+-K+-ATPase and enhances the growth inhibitory effect of digitoxin on human breast cancer cells. Biochem Biophys Res Commun 2008 Oct 31 2
70 19446813 Digitoxin elicits anti-inflammatory and vasoprotective properties in endothelial cells: Therapeutic implications for the treatment of atherosclerosis? Atherosclerosis 2009 Oct 11
71 19487957 Inhibition of the alpha1beta1 isoform of the Na, K-ATPase by 8-methoxycoumestrol without positive inotropic effect in human myocardium--novel aspects of cardiac glycoside pharmacology. J Cardiovasc Pharmacol 2009 Jul 1
72 20206126 Cardiac glycosides potently inhibit C-reactive protein synthesis in human hepatocytes. Biochem Biophys Res Commun 2010 Mar 26 2
73 20388710 Selectivity of digitalis glycosides for isoforms of human Na,K-ATPase. J Biol Chem 2010 Jun 18 1
74 20850842 Cardiac glycosides decrease prostate specific antigen expression by down-regulation of prostate derived Ets factor. J Urol 2010 Nov 3
75 21139994 Digitoxin activates EGR1 and synergizes with paclitaxel on human breast cancer cells. J Carcinog 2010 Nov 18 8
76 21421322 Synthesis and evaluation of cardiac glycoside mimics as potential anticancer drugs. Bioorg Med Chem 2011 Apr 1 1
77 21807619 Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors. J Physiol 2011 Oct 1 2
78 22037315 Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells. Toxicol Appl Pharmacol 2012 Jan 1 1
79 22456266 The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B. RNA 2012 May 8
80 22484270 Interaction of tetramethylpyrazine with two serum albumins by a hybrid spectroscopic method. Spectrochim Acta A Mol Biomol Spectrosc 2012 Jul 1
81 23858296 Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression. J Carcinog 2013 9
82 24045365 Digitoxin sensitizes glioma cells to TRAIL-mediated apoptosis by upregulation of death receptor 5 and downregulation of survivin. Anticancer Drugs 2014 Jan 11
83 24065415 [BNP elevation due to a subdural hematoma - misled by a biomarker]. Dtsch Med Wochenschr 2013 Oct 1
84 24104877 Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovasc Res 2014 Jan 1 1
85 24124520 Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. PLoS One 2013 4
86 24231508 Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation. Biochem Pharmacol 2014 Mar 1 3
87 24754247 Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3. Mol Pharm 2014 Jun 2 1
88 26119931 Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis. Oncogene 2016 Apr 7 1
89 26688208 Evaluation of the binding interaction between bovine serum albumin and dimethyl fumarate, an anti-inflammatory drug by multispectroscopic methods. Spectrochim Acta A Mol Biomol Spectrosc 2016 Mar 5 1
90 26691294 Digitoxin enhances the growth inhibitory effects of thapsigargin and simvastatin on ER negative human breast cancer cells. Fitoterapia 2016 Mar 5
91 26708294 Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays. Toxicol In Vitro 2016 Apr 2
92 26880969 Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model. Stem Cells Int 2016 1
93 26999101 Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation. Molecules 2016 Mar 18 2
94 27431571 Cardiac glycosides display selective efficacy for STK11 mutant lung cancer. Sci Rep 2016 Jul 19 2
95 27504932 Chemoresistance of Lung and Breast Cancer Cells Growing Under Prolonged Periods of Serum Starvation. J Cell Physiol 2017 Aug 5
96 28006108 Digitoxin for Airway Inflammation in Cystic Fibrosis: Preliminary Assessment of Safety, Pharmacokinetics, and Dose Finding. Ann Am Thorac Soc 2017 Feb 2
97 28035421 Digitoxin synergizes with sorafenib to inhibit hepatocelluar carcinoma cell growth without inhibiting cell migration. Mol Med Rep 2017 Feb 2
98 28410215 Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1α in human glioma stem cells. Oncotarget 2017 Jun 20 10
99 28511914 Digitoxin increases sensitivity of glioma stem cells to TRAIL-mediated apoptosis. Neurosci Lett 2017 Jul 13 10
100 28688145 Therapeutic concentrations of digitoxin inhibit endothelial focal adhesion kinase and angiogenesis induced by different growth factors. Br J Pharmacol 2017 Sep 4