8-chloro-cyclic adenosine monophosphate






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1 1617676 Growth inhibition of human glioma cells induced by 8-chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3':5'-monophosphate. Cancer Res 1992 Jul 15 1
2 1688548 8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation. J Biol Chem 1990 Jan 15 11
3 1850725 Inhibitory effect of 8-chloro-cyclic adenosine 3',5'-monophosphate on cell growth of gastric carcinoma cell lines. Jpn J Cancer Res 1991 Mar 5
4 1958031 Regulation of human tumor antigen expression by biological response modifiers (BRMs). Ann Ist Super Sanita 1991 1
5 1998950 8-Chloroadenosine 3',5'-monophosphate inhibits the growth of Chinese hamster ovary and Molt-4 cells through its adenosine metabolite. Cancer Res 1991 Mar 15 2
6 2005412 Epidermal growth factor (EGF) inhibits the secretomotor response of the thyroid: effects of EGF on radioiodine turnover and fluid transport in cultured porcine thyroid cells. J Endocrinol 1991 Feb 1
7 2059204 Cooperative effect of 8-Cl-cAMP and rhGM-CSF on the differentiation of HL-60 human leukemia cells. Biochem Biophys Res Commun 1991 Jun 28 4
8 2157713 Growth factors and oncogenes in human gastrointestinal carcinomas. J Cancer Res Clin Oncol 1990 1
9 2528474 Site-selective 8-Cl-cAMP which causes growth inhibition and differentiation increases DNA (CRE)-binding activity in cancer cells. FEBS Lett 1989 Aug 28 1
10 2536620 Site-selective 8-chloroadenosine 3',5'-cyclic monophosphate inhibits transformation and transforming growth factor alpha production in Ki-ras-transformed rat fibroblasts. FEBS Lett 1989 Jan 2 17
11 2539602 Induction of megakaryocytic differentiation and modulation of protein kinase gene expression by site-selective cAMP analogs in K-562 human leukemic cells. Proc Natl Acad Sci U S A 1989 Apr 2
12 2828506 Thyrotrophin and cyclic AMP regulation of thyroglobulin gene expression in cultured porcine thyroid cells. J Endocrinol 1988 Jan 4
13 7479855 Point mutation of the autophosphorylation site or in the nuclear location signal causes protein kinase A RII beta regulatory subunit to lose its ability to revert transformed fibroblasts. Proc Natl Acad Sci U S A 1995 Nov 7 1
14 7543490 Downregulation of mdr-1 expression by 8-Cl-cAMP in multidrug resistant MCF-7 human breast cancer cells. J Clin Invest 1995 Aug 7
15 7657638 Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action. J Biol Chem 1995 Sep 1 2
16 7831198 Effects of 8-chloro-cyclic adenosine monophosphate on the growth and sensitivity to doxorubicin of multidrug-resistant tumour cell lines. Pharmacol Res 1994 Jul 2
17 7881104 Transcriptional regulation of multidrug resistance in breast cancer. Breast Cancer Res Treat 1994 3
18 7947390 Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts. Cell Growth Differ 1994 Jul 6
19 8094073 Down-regulation of RI alpha subunit of cAMP-dependent protein kinase induces growth inhibition of human mammary epithelial cells transformed by c-Ha-ras and c-erbB-2 proto-oncogenes. Int J Cancer 1993 Feb 1 2
20 8381655 Inhibition of human pancreatic cancer cell (MIA PaCa-2) growth by cholera toxin and 8-chloro-cAMP in vitro. Br J Cancer 1993 Feb 1
21 8449943 8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J Biol Chem 1993 Mar 15 3
22 8562304 Regulation of multidrug resistance through the cAMP and EGF signalling pathways. Cell Signal 1995 Jul 1
23 8886798 Cyclic AMP-induced differentiation increases the synthesis of extracellular superoxide dismutase in rat C6 glioma. Free Radic Biol Med 1996 2
24 9000516 Inhibition of nucleoside diphosphate kinase (NDPK/nm23) by cAMP analogues. FEBS Lett 1997 Jan 2 1
25 9378544 The cAMP analog 8-Cl-cAMP inhibits growth and induces differentiation and apoptosis in retinoblastoma cells. Int J Cancer 1997 Sep 17 1
26 9458366 Regulation of the MDR1 promoter by cyclic AMP-dependent protein kinase and transcription factor Sp1. Int J Oncol 1998 Feb 2
27 9493976 Down-regulation of type I protein kinase A by transfection of human breast cancer cells with an epidermal growth factor receptor antisense expression vector. Breast Cancer Res Treat 1998 Jan 2
28 9563874 Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications. Clin Cancer Res 1998 Apr 1
29 9815703 8-Chloro-cyclic AMP inhibits autocrine and angiogenic growth factor production in human colorectal and breast cancer. Clin Cancer Res 1997 Mar 8
30 9815994 Phase I clinical study with 8-chloro-cAMP and evaluation of immunological effects in cancer patients Clin Cancer Res 1995 Apr 1
31 10208436 Synergistic effects of retinoic acid and 8-Cl-cAMP on apoptosis require caspase-3 activation in human ovarian cancer cells. Oncogene 1999 Mar 4 6
32 10214946 Up-regulated EGF receptors undergo to rapid internalization and ubiquitin-dependent degradation in human cancer cells exposed to 8-Cl-cAMP. FEBS Lett 1999 Mar 26 3
33 10430097 Synergistic effects of retinoic acid and 8-chloro-adenosine 3',5'-cyclic monophosphate on the regulation of retinoic acid receptor beta and apoptosis: involvement of mitochondria. Clin Cancer Res 1999 Jul 1
34 10487712 Treatment of human endometrial gland epithelial cells with chorionic gonadotropin/luteinizing hormone increases the expression of the cyclooxygenase-2 gene. J Clin Endocrinol Metab 1999 Sep 3
35 10584873 8-Cl-cAMP antagonizes mitogen-activated protein kinase activation and cell growth stimulation induced by epidermal growth factor. Br J Cancer 1999 Dec 6
36 10718618 Synergistic effects of 8-Cl-cAMP and retinoic acids in the inhibition of growth and induction of apoptosis in ovarian cancer cells: induction of retinoic acid receptor beta. Mol Cell Biochem 2000 Jan 6
37 10722866 Differential regulation of nitric oxide production by increase of intracellular cAMP in murine primary fibroblasts and L929 fibrosarcoma cell line. Immunol Lett 2000 Mar 1 8
38 10873618 Dual anticancer activity of 8-Cl-cAMP: inhibition of cell proliferation and induction of apoptotic cell death. Biochem Biophys Res Commun 2000 Jul 5 7
39 11129740 8-Cl-cAMP and tiazofurin affect vascular endothelial growth factor production and glial fibrillary acidic protein expression in human glioblastoma cells. Anticancer Drugs 2000 Oct 2
40 11992633 7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine, a potent inhibitor of cAMP-specific phosphodiesterase, enhancing nuclear protein binding to the CRE consensus sequence in human tumour cells. Biochem Pharmacol 2002 Feb 15 4
41 14691008 Disparate effects of thyroid hormone on actions of epidermal growth factor and transforming growth factor-alpha are mediated by 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase II. Endocrinology 2004 Apr 1
42 15002056 PKA- and PKC-dependent regulation of angiopoietin 2 mRNA in human granulosa lutein cells. Horm Metab Res 2004 Feb 4
43 15188002 Activation of protein kinase A (PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy. Br J Cancer 2004 Jul 5 2
44 15334662 8-Cl-cAMP and its metabolite, 8-Cl-adenosine induce growth inhibition in mouse fibroblast DT cells through the same pathways: protein kinase C activation and cyclin B down-regulation. J Cell Physiol 2004 Nov 1
45 15655353 The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival. Cell Cycle 2005 Feb 1
46 15930311 8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells. Cancer Res 2005 Jun 1 7
47 16972264 Rap1 and p38 MAPK mediate 8-chloro-cAMP-induced growth inhibition in mouse fibroblast DT cells. J Cell Physiol 2006 Dec 15
48 17906691 High expression of PKA regulatory subunit 1A protein is related to proliferation of human melanoma cells. Oncogene 2008 Mar 20 5
49 18060599 The combination of gamma ionizing radiation and 8-Cl-cAMP induces synergistic cell growth inhibition and induction of apoptosis in human prostate cancer cells. Invest New Drugs 2008 Aug 1
50 18077011 VIP inhibits human HepG2 cell proliferation in vitro. Regul Pept 2008 Feb 7 1