Thiotepa






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1 403484 [Treatment of advanced breast cancer with alkylating agents]. Minerva Med 1977 Mar 17 4
2 413765 [Genetic control of mutability in laboratory mice. I. Genetic analysis of the sensitivity of mice of strains 101/H and C57BL/6 to the mutagenic effect of thio-TEPA]. Genetika 1977 1
3 1634926 Phase I trial of thiotepa in combination with recombinant human granulocyte-macrophage colony-stimulating factor. J Clin Oncol 1992 Aug 1
4 2105156 Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase. Cancer Res 1990 Feb 1 1
5 2491884 Phase I clinical and pharmacokinetic study of thiotepa administered intraperitoneally in patients with advanced malignancies. J Clin Oncol 1989 Jan 1
6 2504483 Evidence for enzymatic activation and oxygen involvement in cytotoxicity and antitumor activity of N,N',N''-triethylenethiophosphoramide. Cancer Res 1989 Sep 15 2
7 3086117 [Effect of thiophosphamide on ceruloplasmin activity and the copper content of the blood of rabbits]. Farmakol Toksikol 1986 Mar-Apr 1
8 3107916 Enhancement and attenuation of cytogenetic damage by vitamin C in cultured human lymphocytes exposed to thiotepa or L-ethionine. Cytogenet Cell Genet 1987 12
9 4207512 [Vitamin (B-1 and B2) balance and the antitoxic function of the liver under conditions of experimental thiophosphamide therapy]. Farmakol Toksikol 1973 May-Jun 1
10 4251799 [The effect of thiophosphamide on the ATP-ase activity of the strucuural and water-soluble proteins of Guerin carcinoma and its drug resistant variant]. Vopr Med Khim 1970 Jul-Aug 1
11 4306223 [Effect of adrenalectomy, adrenaline and ACTH on the antineoplastic action and antimitotic effect of thiophosphamide]. Farmakol Toksikol 1969 Mar-Apr 1
12 4963995 An experimental comparative study of the distribution of P32-labelled Thio-Tepa and P32 tag. Med Radiol (Mosk) 1967 Apr 1
13 4972953 [Levels of properdin in the serum of rats submitted to the combined effect of zymosan and thio-TEPA]. Klin Lech Zlokach Novoobraz 1968 1
14 5002317 [Reduction of the toxic effect of thio-tepa on mice using anti-somatotropin serum]. Biull Eksp Biol Med 1971 Dec 1
15 7579367 An analysis of engraftment kinetics as a function of the CD34 content of peripheral blood progenitor cell collections in 692 patients after the administration of myeloablative chemotherapy. Blood 1995 Nov 15 1
16 7616408 Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabolism. J Pharmacol Exp Ther 1995 Jul 7
17 7712478 The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa. Cancer Res 1995 Apr 15 10
18 8206865 Cell-adhesive activity and receptor-binding specificity of the laminin-derived YIGSR sequence grafted onto Staphylococcal protein A. J Biochem 1994 Feb 1
19 8475071 Acquired multicellular-mediated resistance to alkylating agents in cancer. Proc Natl Acad Sci U S A 1993 Apr 15 1
20 8612310 A phase I/II study of high-dose cyclophosphamide, cisplatin, and thioTEPA followed by autologous bone marrow and granulocyte colony-stimulating factor-primed peripheral-blood progenitor cells in patients with advanced malignancies. Cancer Chemother Pharmacol 1996 2
21 9548807 Induction of p53 by the concerted actions of aziridine and quinone moieties of diaziquone. Chem Res Toxicol 1998 Apr 1
22 9726020 Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats. Mutat Res 1998 Jul 17 8
23 9788613 Glutathione-dependent biotransformation of the alkylating drug thiotepa and transport of its metabolite monoglutathionylthiotepa in human MCF-7 breast cancer cells. Cancer Res 1998 Oct 15 4
24 10069464 Hprt mutant frequency and molecular analysis of Hprt mutations in Fischer 344 rats treated with thiotepa. Carcinogenesis 1999 Feb 3
25 10334868 Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa. Arch Biochem Biophys 1999 Jun 1 3
26 10482945 Inappropriate antidiuretic hormone secretion after high-dose thiotepa. Bone Marrow Transplant 1999 Sep 1
27 10556952 Hematopoietic stem cell transplantation for childhood myeloid malignancies after high-dose thiotepa, busulfan and cyclophosphamide. Bone Marrow Transplant 1999 Nov 1
28 10634173 CD34+ cell dose requirements for rapid engraftment in a sequential high-dose chemotherapy regimen of paclitaxel, melphalan, and cyclophosphamide, thiotepa, and carboplatin (CTCb) with PBPC support in metastatic breast cancer. J Hematother Stem Cell Res 1999 Aug 1
29 10928097 Influence of co-medicated drugs on the biotransformation of thioTEPA to TEPA and thioTEPA-mercapturate. Anticancer Res 2000 May-Jun 2
30 11431349 Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N',N"-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo. Cancer Res 2001 Jul 1 2
31 11468938 A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide. J Pharmacokinet Pharmacodyn 2001 Jun 1
32 11950782 Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism. Drug Metab Dispos 2002 May 11
33 12107550 Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA. Cancer Chemother Pharmacol 2002 Jun 9
34 12402145 A phase I/II study of 4 monthly courses of high-dose cyclophosphamide and thiotepa for metastatic breast cancer patients. Br J Cancer 2002 Nov 4 1
35 12676886 The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J Pharmacol Exp Ther 2003 Jul 4
36 13944000 [3 cases of bone marrow aplasia, 1 of which is curable, due to triethylene thio-phosphoramide of RP 10, 090]. Lyon Med 1962 Sep 23 1
37 14495833 Isolation perfusion and oxygen saturation: the effect on the binding of P-32 tagged triethylene thiophosphoramide. Surg Forum 1961 1
38 15121764 Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms. J Pharmacol Exp Ther 2004 Sep 4
39 15155554 Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro. Drug Metab Dispos 2004 Jun 3
40 15319333 CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. Drug Metab Dispos 2004 Sep 1
41 15652242 Inhibition of human CYP2B6 by N,N',N''-triethylenethiophosphoramide is irreversible and mechanism-based. Biochem Pharmacol 2005 Feb 1 4
42 15838656 Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism. Cancer Chemother Pharmacol 2005 Oct 2
43 16294610 Bladder cancer: current optimal intravesical treatment. Urol Nurs 2005 Oct 1
44 16874990 Triethylene thiophosphoramide (thio-tepa) and pterygium. Am J Ophthalmol 1966 May 1
45 17003847 RAT CYP3A and CYP2B1/2 were not associated with nevirapine-induced hepatotoxicity. Methods Find Exp Clin Pharmacol 2006 Sep 2
46 17682072 A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6. Drug Metab Dispos 2007 Nov 2
47 19031971 High-dose chemotherapy with autologous stem cell rescue in stage IIIB inflammatory breast cancer. Anticancer Res 2008 Sep-Oct 1
48 19076156 Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa. Br J Clin Pharmacol 2009 Jan 11
49 19616568 Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes. Toxicol Appl Pharmacol 2009 Nov 15 2
50 21196304 DNA methyltransferase inhibitor CDA-2 synergizes with high-dose thiotepa and paclitaxel in killing breast cancer stem cells. Front Biosci (Elite Ed) 2011 Jan 1 4