Organophosphonates






202 Article(s)
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1 7238 Dehydrogenation of the phosphonate analogue of glucose 6-phosphate by glucose 6-phosphate dehydrogenase. Biochem J 1976 Apr 1 1
2 218574 Scalar coupling between 31P and spin-1/2 metal nuclides in 31P NMR of complexes with a ligand containing phosphonate donor groups. Biochem Biophys Res Commun 1979 Jan 30 1
3 566114 Fluorescent phosphonate label for serine hydrolases, pyrenebutyl methylphosphonofluoridate: reaction with acetylcholinesterase. Biochemistry 1978 May 2 1
4 1316735 9-(Phosphonoalkyl)guanine derivatives as substrates or inhibitors of guanylate kinase. Arch Biochem Biophys 1992 Jun 1
5 1446009 Neuropathy target esterase inhibitors: 2-alkyl-, 2-alkoxy-, and 2-(aryloxy)-4H-1,3,2-benzodioxaphosphorin 2-oxides. Chem Res Toxicol 1992 Sep-Oct 1
6 1648965 Binding of phosphonate chelating agents and pyrophosphate to apotransferrin. Biochemistry 1991 Jul 16 1
7 1666291 The pathogenesis of organophosphate polyneuropathy. Crit Rev Toxicol 1991 1
8 1734971 Transition-state characterization: a new approach combining inhibitor analogues and variation in enzyme structure. Biochemistry 1992 Feb 4 1
9 1793011 Phosphonate-phospholipid analogues inhibit human phospholipase A2. Agents Actions 1991 Sep 2
10 1868092 Comparison of the structures of three carboxypeptidase A-phosphonate complexes determined by X-ray crystallography. Biochemistry 1991 Aug 20 4
11 1890690 Phosphylation kinetic constants and oxime-induced reactivation in acetylcholinesterase from fetal bovine serum, bovine caudate nucleus, and electric eel. J Toxicol Environ Health 1991 Sep 1
12 2037866 Competitive irreversible inhibition of enzymes in the presence of a substrate: scope and limitations. J Enzyme Inhib 1991 1
13 2062381 Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution. Nature 1991 Jul 4 1
14 2155036 Direct modulatory effect of hexasodium N,N,N',N'-ethylenediamine-tetramethylene-phosphonate on bone cell function in vitro. Bone Miner 1990 Feb 1
15 2274788 Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue. Science 1990 Dec 14 2
16 2362084 Oxime-induced reactivation of acetylcholinesterase inhibited by organophosphinates. J Appl Toxicol 1990 Apr 2
17 2540397 Evaluation of polyaza macrocyclic methylene phosphonate chelates of Gd3+ ions as MRI contrast agents. Magn Reson Med 1989 Jan 2
18 2611200 Dehydroquinate synthase: the use of substrate analogues to probe the early steps of the catalyzed reaction. Biochemistry 1989 Sep 19 1
19 2836111 Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity. Circulation 1988 Jun 1
20 2892185 The 5'-O-phosphonomethyl analog of ATP. Studies of substrate properties in ligase-dependent reactions. Nucleic Acids Symp Ser 1987 1
21 3385729 Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition. J Med Chem 1988 Jul 1
22 3783578 Nonquaternary cholinesterase reactivators. 3. 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro. J Med Chem 1986 Nov 1
23 6124299 Phosphonate analogues of acidic amino acids: inhibition of excitatory amino acid transmitter binding to cerebellar membranes and of the stimulation of cerebellar cyclic GMP levels. Brain Res 1982 Apr 29 2
24 6299197 A family of phosphohydrolases from bovine intestinal mucosa: 5'-nucleotidase. Arch Biochem Biophys 1983 Jan 2
25 6524218 Effect of para substituents of 2-(N,N-dimethylamino)ethyl phenyl phenylphosphonates on inhibition of human pseudocholinesterase. Acta Chem Scand B 1984 1
26 7619798 Origins and diversity of the aging reaction in phosphonate adducts of serine hydrolase enzymes: what characteristics of the active site do they probe? Biochemistry 1995 Jul 18 2
27 7739015 Phosphonates and phosphinates: novel leaving groups for benzisothiazolone inhibitors of human leukocyte elastase. J Med Chem 1995 Apr 28 2
28 8180211 Phospholipid determinants for annexin V binding sites and the role of tryptophan 187. Biochemistry 1994 May 17 1
29 8253196 Nucleoside triphosphatase activity associated with the N-terminal domain of mammalian tryptophanyl-tRNA synthetase. FEBS Lett 1993 Dec 6 1
30 8280765 Digestive lipases: inactivation by phosphonates. Biochim Biophys Acta 1994 Jan 3 2
31 8343991 Symposium introduction: retrospect and prospects for neuropathy target esterase (NTE) and the delayed polyneuropathy (OPIDP) induced by some organophosphorus esters. Chem Biol Interact 1993 Jun 1
32 8344001 The R-(+)isomer of O-n-hexyl S-methyl phosphorothioamidate causes delayed neuropathy in hens after generation of a form of inhibited neuropathy target esterase (NTE) which can be reactivated ex vivo. Chem Biol Interact 1993 Jun 2
33 8492300 Interactions in vitro of some organophosphoramidates with neuropathy target esterase and acetylcholinesterase of hen brain. J Biochem Toxicol 1993 Mar 4
34 8518293 Phosphonate inhibitors of glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase. Biochim Biophys Acta 1993 Jun 24 1
35 8524836 Crystal structure of the complex of a catalytic antibody Fab fragment with a transition state analog: structural similarities in esterase-like catalytic antibodies. Proc Natl Acad Sci U S A 1995 Dec 5 1
36 8540751 Synthesis, antiviral activity and enzymatic phosphorylation of 9-phosphonopentenyl derivatives of guanine. Antiviral Res 1995 Jun 1
37 8558536 Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase. J Med Chem 1996 Jan 19 2
38 8632418 Guanine, pyrazolo[3,4-d]pyrimidine, and triazolo[4,5-d]pyrimidine (8-azaguanine) phosphonate acyclic derivatives as inhibitors of purine nucleoside phosphorylase. J Med Chem 1996 Feb 16 1
39 8650700 Steroidal alkenylphosphonates via palladium-catalyzed coupling reactions. Steroids 1995 Dec 1
40 8676336 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. J Med Chem 1996 Mar 1 1
41 8718893 Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates. Biochemistry 1996 Aug 20 1
42 8896442 The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. EMBO J 1996 Oct 15 1
43 8896828 Persistent depression of synaptic responses occurs in quisqualate sensitized hippocampal slices after exposure to L-aspartate-beta-hydroxamate. Brain Res 1996 Sep 23 1
44 8951913 2-aminoethylphosphonic acid: biodistribution of a naturally occurring phosphonate after labelling with technetium-99m. Nucl Med Commun 1996 Oct 1
45 8997900 Phosphono analogues of glutathione as new inhibitors of glutathione S-transferases. Arch Pharm (Weinheim) 1996 Nov 1
46 9062133 Highly potent irreversible inhibitors of neutrophil elastase generated by selection from a randomized DNA-valine phosphonate library. Biochemistry 1997 Mar 11 3
47 9354233 Structure-activity studies of the inhibition of serine beta-lactamases by phosphonate monoesters. Bioorg Med Chem 1997 Sep 1
48 9636049 Nucleotide and nucleoside analogues as inhibitors of cytosolic 5'-nucleotidase I from heart. Biochemistry 1998 Jun 23 3
49 9647673 Mechanism-based inhibition of human folylpolyglutamate synthetase: design, synthesis, and biochemical characterization of a phosphapeptide mimic of the tetrahedral intermediate. Arch Biochem Biophys 1998 Jul 1 4
50 9922143 Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry 1998 Dec 22 2