NT157






11 Article(s)
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1 26029165 Preclinical Effectiveness of Selective Inhibitor of IRS-1/2 NT157 in Osteosarcoma Cell Lines. Front Endocrinol (Lausanne) 2015 1
2 28453463 The IGF-I/JAK2-STAT3/miR-21 signaling pathway may be associated with human renal cell carcinoma cell growth. Cancer Biomark 2017 Jul 4 1
3 28583713 IGF-1R signalling contributes to IL-6 production and T cell dependent inflammation in rheumatoid arthritis. Biochim Biophys Acta Mol Basis Dis 2017 Sep 2
4 29731870 IGF-1-induced MMP-11 expression promotes the proliferation and invasion of gastric cancer cells through the JAK1/STAT3 signaling pathway. Oncol Lett 2018 May 3
5 29736736 The Medial Septum Is Insulin Resistant in the AD Presymptomatic Phase: Rescue by Nerve Growth Factor-Driven IRS<sub>1</sub> Activation. Mol Neurobiol 2019 Jan 3
6 30229539 Insulin Receptor Substrate Suppression by the Tyrphostin NT157 Inhibits Responses to Insulin-Like Growth Factor-I and Insulin in Breast Cancer Cells. Horm Cancer 2018 Dec 4
7 31042587 IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells. Cancer Lett 2019 Aug 1 9
8 32296029 NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2<sup>V617F</sup>-positive myeloproliferative neoplasm cells. Signal Transduct Target Ther 2020 Jan 24 16
9 33007330 FGFR1 overexpression renders breast cancer cells resistant to metformin through activation of IRS1/ERK signaling. Biochim Biophys Acta Mol Cell Res 2021 Jan 4
10 33403501 NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia. Invest New Drugs 2021 Jun 4
11 34238066 NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway. Technol Cancer Res Treat 2021 Jan-Dec 2