Pyrazines






131 Article(s)
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1 12825 Oxidation of methyl derivatives of pteridin-4-one, lumazine and related pteridines by bovine milk xanthine oxidase. Biochim Biophys Acta 1977 Jan 11 2
2 1553756 Differences between rats and rabbits in hepatic cytosolic glutathione S-transferase expression in response to nitrogen heterocycle and other inducers. Toxicol Appl Pharmacol 1992 Mar 4
3 1705099 Distinct epitopes on amiloride. II. Variably restricted epitopes defined by monoclonal anti-amiloride antibodies. Am J Physiol 1991 Feb 1
4 2586490 Relative substrate activities of structurally related pteridine, quinazoline, and pyrimidine analogs for mouse liver folylpolyglutamate synthetase. Mol Pharmacol 1989 Nov 1
5 3523479 Odorant-binding protein: localization to nasal glands and secretions. Proc Natl Acad Sci U S A 1986 Jul 1
6 4052398 Proton NMR of aequorin. Structural changes concomitant with calcium-independent light emission. Biochemistry 1985 Jul 30 1
7 7689039 Induction of rat liver microsomal epoxide hydrolase by thiazole and pyrazine: hydrolysis of 2-cyanoethylene oxide. Carcinogenesis 1993 Aug 11
8 8109728 Pyrazine compounds and the measurement of cytosolic Ca2+. Anal Biochem 1993 Nov 1 1
9 8117321 Inhibition of cytochrome P4502E1 expression by organosulfur compounds allylsulfide, allylmercaptan and allylmethylsulfide in rats. Biochem Pharmacol 1994 Feb 9 4
10 8117322 Enhanced expression of rat microsomal epoxide hydrolase gene by organosulfur compounds. Biochem Pharmacol 1994 Feb 9 5
11 8410980 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. J Med Chem 1993 Sep 3 1
12 8498080 Effect of treatment with pyrazine and some derivatives on cytochrome P450 and some enzyme activities in rat liver. Xenobiotica 1993 Feb 2
13 8602879 Enzymology of the reduction of the novel fused pyrazine mono-n-oxide bioreductive drug, RB90740 roles for P450 reductase and cytochrome b5 reductase. Biochem Pharmacol 1996 Mar 22 1
14 8644120 Inorganic tin -- a new selective inducer of the murine coumarin 7-hydroxylase (CYP2A5). Toxicology 1996 Apr 15 2
15 9083490 New non-peptide endothelin-A receptor antagonists: synthesis, biological properties, and structure-activity relationships of 5-(dimethylamino)-N-pyridyl-,-N-pyrimidinyl-,-N-pyridazinyl-, and -N-pyrazinyl-1-naphthalenesulfonamides. J Med Chem 1997 Mar 14 2
16 9827574 Lipopolysaccharide inhibition of rat hepatic microsomal epoxide hydrolase and glutathione S-transferase gene expression irrespective of nuclear factor-kappaB activation. Biochem Pharmacol 1998 Dec 1 1
17 9920464 Differential induction of rat hepatic microsomal epoxide hydrolase and rGSTA2 by diazines: the role of cytochrome P450 2E1-mediated metabolic activation. Chem Biol Interact 1998 Nov 27 2
18 10888564 Volatile compounds produced from monosodium glutamate in common food cooking. J Agric Food Chem 2000 Jun 1
19 11429903 Single-component organic semiconductors based on novel radicals that exhibit electrochemical amphotericity: preparation, crystal structures, and solid-state properties of N,N'-dicyanopyrazinonaphthoquinodiiminides substituted with an N-alkylpyridinium unit. J Org Chem 2001 Jan 12 1
20 11557356 Synthesis and evaluation of diazine containing bioisosteres of (-)-ferruginine as ligands for nicotinic acetylcholine receptors. Bioorg Med Chem 2001 Oct 1
21 11751466 Odorants of different chemical classes interact with distinct odorant binding protein subtypes. Chem Senses 2002 Jan 2
22 11937337 Synthesis and biological evaluation of aroylguanidines related to amiloride as inhibitors of the human platelet Na(+)/H(+) exchanger. Bioorg Med Chem 2002 Jun 2
23 12499594 Hydrophobicity parameters determined by reversed-phase liquid chromatography. XV: optimal conditions for prediction of log P(oct) by using RP-HPLC procedures. Chem Pharm Bull (Tokyo) 2002 Dec 1
24 12538029 Estrogenic diazenes: heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypes. Bioorg Med Chem 2003 Feb 20 6
25 12832126 An overview of inhibitors of Na(+)/H(+) exchanger. Eur J Med Chem 2003 Jun 2
26 15252617 Various forms of linear dipyridyls in discrete rectangles, dinuclear rods, and one-dimensional networks containing (eta5-pentamethylcyclopentadienyl)rhodium(III). Dalton Trans 2004 May 21 6
27 15497993 Stereochemistry of C-6 nucleophilic displacements on 1,1-difluorocyclopropyldibenzosuberanyl substrates. An improved synthesis of multidrug resistance modulator LY335979 trihydrochloride. J Org Chem 2004 Oct 29 1
28 15540127 Synthesis and structure of Zn7(mu4-O)2(OAc)10(Pz)2(OAc = acetate; Pz = pyrazine). Dalton Trans 2004 Nov 21 1
29 15548092 N-h insertion reactions of Boc-amino acid amides: solution- and solid-phase synthesis of pyrazinones and pyrazines. Org Lett 2004 Nov 25 1
30 16028905 High-performance organic field-effect transistors based on pi-extended tetrathiafulvalene derivatives. J Am Chem Soc 2005 Jul 27 1
31 16392826 Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead. J Med Chem 2006 Jan 12 1
32 16878965 On the preparation of coordination polymers by controlled thermal decomposition: synthesis, crystal structures, and thermal properties of zinc halide pyrazine coordination compounds. Inorg Chem 2006 Aug 7 1
33 17136238 [Cu(HF2)(pyz)2]BF4 (pyz = pyrazine): long-range magnetic ordering in a pseudo-cubic coordination polymer comprised of bridging HF2- and pyrazine ligands. Chem Commun (Camb) 2006 Dec 21 1
34 17685602 Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction. J Med Chem 2007 Sep 6 1
35 17700826 Closed-pore crystal capable of adsorbing CO2 onto isolated cavities generated by disorderly mixing of substituents on host skeleton. Dalton Trans 2007 Sep 7 1
36 18047304 Competition between photochemistry and energy transfer in UV-excited diazabenzenes. 4. UV photodissociation of 2,3-, 2,5-, and 2,6-dimethylpyrazine. J Phys Chem A 2007 Dec 27 3
37 18473434 Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2,6-disubstituted pyrazine scaffold. J Med Chem 2008 Jun 12 1
38 18975868 New strategy for quantifying biological zinc by a modified zinpyr fluorescence sensor. J Am Chem Soc 2008 Nov 26 1
39 19002334 A new five-coordinated CuIP2NO2 system: XRD structure of 6-acetyl-1,3,7-trimethyl-pteridine-2,4(1H,3H)-dione and its Cu(I) (N5,O61,O4)-tridentate complex with triphenylphosphine. An AIM study of the nature of metal-ligand bonds. Dalton Trans 2008 Dec 7 1
40 19343742 Pyrazine arotinoids with inverse agonist activities on the retinoid and rexinoid receptors. Chembiochem 2009 May 4 12
41 19778056 Isotope labeling studies on the origin of 3,4-hexanedione and 1,2-butanedione in an alanine/glucose model system. J Agric Food Chem 2009 Oct 28 2
42 19914063 Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett 2010 Jan 1 1
43 20034844 DFT study of chemical mechanism of pre-SERS spectra in Pyrazine-metal complex and metal-Pyrazine-metal junction. Spectrochim Acta A Mol Biomol Spectrosc 2010 Feb 3
44 20187041 Synthesis and self-aggregation of enantiopure and racemic molecular tweezers based on the bicyclo[3.3.1]nonane framework. Chemistry 2010 Apr 6 1
45 20965738 Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain. Bioorg Med Chem 2010 Nov 15 1
46 20976340 Synthesis, structure and magnetic properties of two new azido-Co(II) coordination architectures: from ferromagnetic coupling to single-chain-magnets. Dalton Trans 2010 Dec 14 2
47 21618986 Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist. J Med Chem 2011 Jun 23 2
48 21954325 Molecular recognition effects in atomistic models of imprinted polymers. Int J Mol Sci 2011 3
49 21962147 Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent α4β2 nicotinic acetylcholine receptor ligands. J Med Chem 2011 Nov 10 1
50 22040023 Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1). J Med Chem 2011 Dec 22 1