Taurochenodeoxycholic Acid






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1 812551 Effect of bile salts on lactosylceramide beta-galactosidase activities in human brain, liver and cultured skin fibroblasts. Biochim Biophys Acta 1975 Dec 17 1
2 1824011 Differentiation of isomeric conjugated bile acids using positive-ion B/E linked scans. Anal Chem 1991 Feb 1 3
3 2222431 Tauroursodeoxycholic acid inhibits the cytosolic Ca++ increase in human neutrophils stimulated by formyl-methionyl-leucyl-phenylalanine. Biochem Biophys Res Commun 1990 Sep 28 6
4 3095476 Characterization of 6 alpha-hydroxylation of taurochenodeoxycholic acid in pig liver. J Lipid Res 1986 Aug 1
5 6316931 Effect of taurochenodeoxycholate or tauroursodeoxycholate upon biliary output of phospholipids and plasma-membrane enzymes, and the extent of cell damage, in isolated perfused rat livers. Biochem J 1983 Oct 15 2
6 6503620 The effect of neurotensin on the concentration of cholesterol and bile acids in the guinea pig. Lipids 1984 Oct 3
7 7560859 Enhanced biliary excretion of canalicular membrane enzymes in estrogen-induced and obstructive cholestasis, and effects of different bile acids in the isolated perfused rat liver. J Hepatol 1995 Jun 4
8 7649186 Characterisation of taurochenodeoxycholic acid 6 alpha-hydroxylase from pig liver microsomes. Eur J Biochem 1995 Aug 1 3
9 7766669 Enzymatic characterization of a novel bovine liver dihydrodiol dehydrogenase--reaction mechanism and bile acid dehydrogenase activity. Biochim Biophys Acta 1995 May 11 1
10 8026274 Biliary lipid composition in heterozygous familial hypercholesterolemia and influence of treatment with probucol. Dig Dis Sci 1994 Jul 1
11 8743917 Differential effects between tauroursodeoxycholic and taurochenodeoxycholic acids in hepatic fibrosis: an assessment by primary cultured Ito and Kupffer cells from the rat liver. J Gastroenterol Hepatol 1996 May 3
12 8938553 Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J Hepatol 1996 Nov 2
13 8938554 Vasopressin reduces taurochenodeoxycholate-induced hepatotoxicity by lowering the hepatocyte taurochenodeoxycholate content. J Hepatol 1996 Nov 9
14 9041261 Regulation of mucin secretion in human gallbladder epithelial cells: predominant role of calcium and protein kinase C. Gastroenterology 1997 Mar 2
15 9428230 Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat. Gastroenterology 1998 Jan 2
16 9458268 Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation. J Lipid Res 1997 Dec 1
17 9508521 Elevated biliary calmodulin during gallstone formation: the role of bile acids. Dig Dis Sci 1998 Jan 3
18 9545351 The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 1998 Apr 17 1
19 9950808 Regulation of apolipoprotein secretion by biliary lipids in newborn swine intestinal epithelial cells. Am J Physiol 1999 Feb 1
20 10216279 6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes. Biochim Biophys Acta 1999 Apr 19 8
21 11113117 Cloning and expression of a pig liver taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily. J Biol Chem 2001 Mar 30 1
22 11166007 Physiologic concentrations of bile salts inhibit rat hepatic alkaline phosphatase but not the intestinal isoenzyme. Clin Biochem 2000 Nov 2
23 11230727 Bile acid transport and regulating functions in the human biliary epithelium. Hepatology 2001 Mar 1
24 11230738 Bile acids induce eosinophil degranulation by two different mechanisms. Hepatology 2001 Mar 2
25 11292547 The effect of absorption enhancers on the initial degradation kinetics of insulin by alpha-chymotrypsin. Int J Pharm 2001 Apr 17 1
26 11343252 Characterization of the mouse bile salt export pump overexpressed in the baculovirus system. Hepatology 2001 May 1
27 11375961 The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes. Gastroenterology 2001 Jun 5
28 11882418 Effects of secretin on TCDCA- or TDCA-induced cholestatic liver injury in the rat. Hepatol Res 2002 Mar 4
29 12065295 Effects of bile acids on the muscle functions of guinea pig gallbladder. Am J Physiol Gastrointest Liver Physiol 2002 Jul 3
30 12085348 Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. Hepatology 2002 Jul 2
31 12151345 Bile acids mimic oxidative stress induced upregulation of thioredoxin reductase in colon cancer cell lines. Carcinogenesis 2002 Aug 4
32 12404240 Functional expression of the canalicular bile salt export pump of human liver. Gastroenterology 2002 Nov 1
33 12421748 Bile salts potentiate adenylyl cyclase activity and cAMP-regulated secretion in human gallbladder epithelium. Am J Physiol Gastrointest Liver Physiol 2003 Feb 3
34 12845961 Taurochenodeoxycholic acid induced biphasic hepatotoxicity in isolated perfused rat liver: roles of Ca2+ and calpain. Hepatogastroenterology 2003 Jul-Aug 3
35 14656949 Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines. Carcinogenesis 2004 Mar 3
36 15746212 Phosphatidylinositol 3-kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers. Am J Physiol Gastrointest Liver Physiol 2005 Jul 3
37 16255717 Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity. Biochem J 2006 Feb 15 1
38 16282361 Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione. Am J Physiol Gastrointest Liver Physiol 2006 Apr 1
39 17074018 Chenodeoxycholic acid and taurochenodexycholic acid induce anti-apoptotic cIAP-1 expression in human hepatocytes. J Gastroenterol Hepatol 2006 Dec 4
40 17434532 Structural basis for bile salt inhibition of pancreatic phospholipase A2. J Mol Biol 2007 Jun 1 1
41 17435549 Bile salts induce resistance to apoptosis through NF-kappaB-mediated XIAP expression. Ann Surg 2007 Mar 3
42 18700187 Retrieval of the rat canalicular conjugate export pump Mrp2 is associated with a rearrangement of actin filaments and radixin in bile salt-induced cholestasis. Eur J Med Res 2008 Jul 28 4
43 19008001 Cloning and molecular characterization of apical efflux transporters (ABCB1, ABCB11 and ABCC2) in rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat Toxicol 2008 Dec 11 2
44 19029016 Mouse Bsep ATPase assay: a nonradioactive tool for assessment of the cholestatic potential of drugs. J Biomol Screen 2009 Jan 5
45 19553664 Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. J Biol Chem 2009 Aug 14 1
46 21039722 The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin. Clin Endocrinol (Oxf) 2011 Jan 1
47 21983642 Effects of taurochenodeoxycholic acid on adjuvant arthritis in rats. Int Immunopharmacol 2011 Dec 12
48 22492528 Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition. Diabetes 2012 Jun 1
49 22806967 Short-term feedback regulation of bile salt uptake by bile salts in rodent liver. Hepatology 2012 Dec 7
50 23510744 Taurochenodeoxycholic acid induces apoptosis of fibroblast-like synoviocytes. Eur J Pharmacol 2013 Apr 15 2