Edaravone






327 Article(s)
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1 6508979 Influence of rifampicin treatment on antipyrine clearance and metabolite formation in patients with tuberculosis. Br J Clin Pharmacol 1984 Nov 1
2 6971920 Synthesis of C-11 iodoantipyrine for positron emission tomography. J Nucl Med 1981 Jun 1
3 8681486 Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther 1996 Jun 3
4 9262182 Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia. Brain Res 1997 Jul 11 1
5 12792822 The free radical scavenger edaravone suppresses experimental dextran sulfate sodium-induced colitis in rats. Int J Mol Med 2003 Jul 4
6 12795759 Clinical usefulness of edaravone for acute liver injury. J Gastroenterol Hepatol 2003 Jul 3
7 12954792 Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J Pharmacol Exp Ther 2003 Oct 2
8 12969758 Normalization by edaravone, a free radical scavenger, of irradiation-reduced endothelial nitric oxide synthase expression. Eur J Pharmacol 2003 Aug 22 4
9 14567445 A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury. Free Radic Res 2003 Aug 6
10 14604280 N-(4-Hydroxyphenyl)retinamide (4-HPR) induces leukemia cell death via generation of reactive oxygen species. Int J Hematol 2003 Oct 1
11 14654979 Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats. Int J Mol Med 2004 Jan 1
12 14768352 [Alterations of antiproliferative effects of serum obtained from patients with acute cerebral infarction treated with a radical scavenger, edaravone, with or without amlodipine using an in vitro cultured basilar artery smooth muscle cells]. Yakugaku Zasshi 2004 Jan 1
13 15142331 Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain. Neurol Res 2004 Apr 5
14 15178695 Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction. J Pharmacol Exp Ther 2004 Oct 5
15 15239999 A new free radical scavenger, edaravone, ameliorates oxidative liver damage due to ischemia-reperfusion in vitro and in vivo. J Gastrointest Surg 2004 Jul-Aug 3
16 15246699 Neuroprotection of edaravone on hypoxic-ischemic brain injury in neonatal rats. Brain Res Dev Brain Res 2004 Jul 19 1
17 15629513 Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats. J Hepatol 2005 Jan 3
18 15629865 Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. Free Radic Biol Med 2005 Feb 1 1
19 15695167 The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia. Neuropharmacology 2005 Feb 1
20 15721014 Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthase. Atherosclerosis 2005 Mar 10
21 15824197 The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy. Hypertension 2005 May 1
22 15891337 A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model. Crit Care Med 2005 May 2
23 15921675 Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. Eur J Pharmacol 2005 Jun 1 4
24 15978175 Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: evaluation in a rat thromboembolic stroke model. Neurol Res 2005 Jul 3
25 16095811 The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB. Cancer Lett 2005 Nov 18 2
26 16166574 Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. Stroke 2005 Oct 1
27 16198237 Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction. Free Radic Biol Med 2005 Oct 15 2
28 16330705 Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure. Circulation 2005 Dec 6 1
29 16390820 Edaravone inhibits rheumatoid synovial cell proliferation and migration. Free Radic Res 2006 Feb 2
30 16391834 The free radical scavengers edaravone and tempol suppress experimental dextran sulfate sodium-induced colitis in mice. Int J Mol Med 2006 Feb 2
31 16427299 MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation. Eur J Cardiothorac Surg 2006 Mar 8
32 16545576 Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic rats. Pharmacol Res 2006 Jul 3
33 16550312 Inhibitory effects of edaravone on the production of tumor necrosis factor-alpha in the isolated heart undergoing ischemia and reperfusion. Heart Vessels 2006 Mar 4
34 16580698 An antioxidant treatment potentially protects myocardial energy metabolism by regulating uncoupling protein 2 expression in a chronic beta-adrenergic stimulation rat model. Life Sci 2006 May 15 1
35 16595905 Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats. Biol Pharm Bull 2006 Apr 2
36 16635056 Edaravone inhibits the disease activity in rheumatoid arthritis. J Clin Pharm Ther 2006 Apr 1
37 16799234 Long-term efficacy of edaravone in patients with acute myocardial infarction. Circ J 2006 Jul 1
38 16806227 Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis. Atherosclerosis 2007 Apr 3
39 16834755 Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev 2006 Spring 2
40 16872585 Susceptibility of brain microvascular endothelial cells to advanced glycation end products-induced tissue factor upregulation is associated with intracellular reactive oxygen species. Brain Res 2006 Sep 7 3
41 16909478 Edaravone protects PC12 cells from ischemic-like injury via attenuating the damage to mitochondria. J Zhejiang Univ Sci B 2006 Sep 6
42 17064733 Edaravone reduces ischemia-reperfusion injury mediators in rat liver. J Surg Res 2007 Jan 3
43 17112405 Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice. Acta Pharmacol Sin 2006 Dec 1
44 17329838 Effects of edaravone in heart of aged rats after cerebral ischemia-reperfusion injury. Biol Pharm Bull 2007 Mar 2
45 17356309 Hydroxyl radical mediates the augmented angiotensin II responses in thoracic aorta of spontaneously hypertensive rats. Pharmacology 2007 2
46 17502342 Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate. Drug Metab Dispos 2007 Aug 14
47 17521626 Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy. Eur J Pharmacol 2007 Jul 30 1
48 17626263 Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radical scavenger. Glia 2007 Oct 3
49 17629561 Edaravone inhibits collagen-induced arthritis possibly through suppression of nuclear factor-kappa B. Mol Immunol 2008 Jan 8
50 17682070 Evaluation of the role of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in the urinary excretion of sulfate and glucuronide metabolites of edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one). Drug Metab Dispos 2007 Nov 5