Pyruvaldehyde






895 Article(s)
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51 9175718 Inactivation of glutathione reductase by 4-hydroxynonenal and other endogenous aldehydes. Biochem Pharmacol 1997 Apr 25 2
52 9191294 Induction of TNF alpha and IL-1 beta mRNA in monocytes by methylglyoxal- and advanced glycated endproduct-modified human serum albumin. Biochem Soc Trans 1997 May 2
53 9218489 Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogenesis in diabetes. J Biol Chem 1997 Jul 18 6
54 9359858 Mutagenesis of residue 157 in the active site of human glyoxalase I. Biochem J 1997 Nov 15 1
55 9446106 [The role of methylglyoxal in the development of diabetic complications]. Postepy Hig Med Dosw 1997 2
56 9446611 Expression of the glyoxalase I gene of Saccharomyces cerevisiae is regulated by high osmolarity glycerol mitogen-activated protein kinase pathway in osmotic stress response. J Biol Chem 1998 Jan 30 2
57 9450641 Inactivation of glyceraldehyde-3-phosphate dehydrogenase of human malignant cells by methylglyoxal. Mol Cell Biochem 1997 Dec 10
58 9486985 Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis. J Clin Invest 1998 Mar 1 2
59 9525289 Adaptive response of human melanoma cells to methylglyoxal injury. Carcinogenesis 1998 Mar 1
60 9538214 Overexpression of aldehyde reductase protects PC12 cells from the cytotoxicity of methylglyoxal or 3-deoxyglucosone. J Biochem 1998 Feb 2
61 9572061 Potential therapeutic value of drugs inhibiting semicarbazide-sensitive amine oxidase: vascular cytoprotection in diabetes mellitus. Pharmacol Res 1998 Feb 1
62 9737992 Oxidation-reduction properties of methylglyoxal-modified protein in relation to free radical generation. J Biol Chem 1998 Sep 25 3
63 9787766 Methylglyoxal as substrate and inhibitor of human aldehyde dehydrogenase: comparison of kinetic properties among the three isozymes. Comp Biochem Physiol B Biochem Mol Biol 1998 Apr 2
64 9839528 Deamination of methylamine and aminoacetone increases aldehydes and oxidative stress in rats. Life Sci 1998 2
65 9846896 Chemical modification of proteins by methylglyoxal. Cell Mol Biol (Noisy-le-grand) 1998 Nov 1
66 9925727 Mechanism-based competitive inhibitors of glyoxalase I: intracellular delivery, in vitro antitumor activities, and stabilities in human serum and mouse serum. J Med Chem 1999 Jan 28 1
67 10206549 Synthesis and activity of gamma-(L-gamma-azaglutamyl)-S-(p-bromobenzyl)-L-cysteinylglycine: a metabolically stable inhibitor of glyoxalase I. Bioorg Med Chem Lett 1999 Mar 22 1
68 10352726 The cytotoxicity of methylglyoxal and 3-deoxyglucosone is decreased in the aldehyde reductase gene-transfected cells. Adv Exp Med Biol 1999 1
69 10413301 Accumulation of alpha-oxoaldehydes during oxidative stress: a role in cytotoxicity. Biochem Pharmacol 1999 Aug 15 1
70 10497785 Simultaneous determination of formaldehyde and methylglyoxal in urine: involvement of semicarbazide-sensitive amine oxidase-mediated deamination in diabetic complications. J Chromatogr Sci 1999 Sep 3
71 10510318 Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. Biochem J 1999 Oct 15 1
72 10548540 Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem J 1999 Nov 15 3
73 10564821 Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation. Gene 1999 Nov 15 1
74 10606733 Glucose degradation product methylglyoxal enhances the production of vascular endothelial growth factor in peritoneal cells: role in the functional and morphological alterations of peritoneal membranes in peritoneal dialysis. FEBS Lett 1999 Dec 17 3
75 10666306 Cloning and characterization of glyoxalase I from soybean. Arch Biochem Biophys 2000 Feb 15 1
76 10712823 Maillard reactions in lens proteins: methylglyoxal-mediated modifications in the rat lens. Exp Eye Res 2000 Mar 1
77 10723098 Methylglyoxal induces apoptosis in Jurkat leukemia T cells by activating c-Jun N-terminal kinase. J Cell Biochem 2000 Mar 8
78 10752532 Effect of glucose degradation products on human peritoneal mesothelial cell function. J Am Soc Nephrol 2000 Apr 2
79 10828676 Methylglyoxal-induced apoptosis in human prostate carcinoma: potential modality for prostate cancer treatment. Eur Urol 2000 Jun 1
80 10913283 Determination of the structure of Escherichia coli glyoxalase I suggests a structural basis for differential metal activation. Biochemistry 2000 Aug 1 1
81 10942318 Inhibition of gastric mucosal damage by methylglyoxal pretreatment in rats. Food Chem Toxicol 2000 Jul 2
82 10972486 Pharmacokinetics and antitumor properties in tumor-bearing mice of an enediol analogue inhibitor of glyoxalase I. Cancer Chemother Pharmacol 2000 1
83 11139585 A 33-kDa allergen from rice (Oryza sativa L. Japonica). cDNA cloning, expression, and identification as a novel glyoxalase I. J Biol Chem 2001 Apr 6 1
84 11266660 2-Bromoethylamine as a potent selective suicide inhibitor for semicarbazide-sensitive amine oxidase. Biochem Pharmacol 2001 Mar 15 2
85 11306074 Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications. Chem Biol Interact 2001 Jan 30 7
86 11315838 alpha-Dicarbonyls increase in the postprandial period and reflect the degree of hyperglycemia. Diabetes Care 2001 Apr 1
87 11368170 Brief history of glyoxalase I and what we have learned about metal ion-dependent, enzyme-catalyzed isomerizations. Arch Biochem Biophys 2001 Mar 1 1
88 11425486 Glyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in human endothelial cells. Free Radic Biol Med 2001 Jul 1 25
89 11459475 Active site structure and mechanism of human glyoxalase I-an ab initio theoretical study. J Am Chem Soc 2001 Jul 25 1
90 11489834 Selective activation of apoptosis program by S-p-bromobenzylglutathione cyclopentyl diester in glyoxalase I-overexpressing human lung cancer cells. Clin Cancer Res 2001 Aug 2
91 11498280 Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process. Free Radic Biol Med 2001 Aug 15 7
92 11525399 The Saccharomyces cerevisiae aldose reductase is implied in the metabolism of methylglyoxal in response to stress conditions. Curr Genet 2001 Jul 2
93 11705701 Glyoxal and methylglyoxal induce lyoxal and methyglyoxal induce aggregation and inactivation of ERK in human endothelial cells. Free Radic Biol Med 2001 Nov 15 5
94 11707430 Methylglyoxal enhances cisplatin-induced cytotoxicity by activating protein kinase Cdelta. J Biol Chem 2002 Jan 25 12
95 11792832 Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE. Proc Natl Acad Sci U S A 2002 Jan 22 7
96 11848206 Generation of superoxide anions during the reaction of guanidino compounds with methylglyoxal. Chem Pharm Bull (Tokyo) 2002 Feb 2
97 11897769 Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells. Hypertension 2002 Mar 1 2
98 11955284 D-Lactate transport and metabolism in rat liver mitochondria. Biochem J 2002 Jul 15 1
99 11961137 Substrate-induced up-regulation of aldose reductase by methylglyoxal, a reactive oxoaldehyde elevated in diabetes. Mol Pharmacol 2002 May 13
100 11978653 Advanced glycation end product precursors impair epidermal growth factor receptor signaling. Diabetes 2002 May 5