geranylgeranyl pyrophosphate






309 Article(s)
Download
PMID
Title
Journal
Pub. Date
#Total Relationship(s)
1 1902099 A geranylgeranyltransferase for rhoA p21 distinct from the farnesyltransferase for ras p21S. Biochem Biophys Res Commun 1991 Mar 15 6
2 7665600 BTS1 encodes a geranylgeranyl diphosphate synthase in Saccharomyces cerevisiae. J Biol Chem 1995 Sep 15 2
3 7696880 Cloning and characterization of the maize An1 gene. Plant Cell 1995 Jan 1
4 7994182 The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis. Plant Cell 1994 Oct 1
5 8148370 Molecular cloning and characterization of an isoprenylated 67 kDa protein. Biochim Biophys Acta 1994 Apr 6 1
6 8232542 Bet2p and Mad2p are components of a prenyltransferase that adds geranylgeranyl onto Ypt1p and Sec4p. Nature 1993 Nov 4 2
7 8756702 Yeast geranylgeranyltransferase type-II: steady state kinetic studies of the recombinant enzyme. Biochemistry 1996 Aug 13 1
8 8972729 Generation of antibodies specific for the RalA and RalB GTP-binding proteins and determination of their concentration and distribution in human platelets. Biochim Biophys Acta 1996 Nov 8 4
9 8986756 Regulation of product chain length by isoprenyl diphosphate synthases. Proc Natl Acad Sci U S A 1996 Dec 24 2
10 8995216 Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. J Biol Chem 1997 Jan 3 5
11 9193076 Transgenic rice (Oryza sativa) endosperm expressing daffodil (Narcissus pseudonarcissus) phytoene synthase accumulates phytoene, a key intermediate of provitamin A biosynthesis. Plant J 1997 May 1
12 9221828 Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. Toxicol Appl Pharmacol 1997 Jul 1
13 9349257 Geranylgeranyl pyrophosphate synthase encoded by the newly isolated gene GGPS6 from Arabidopsis thaliana is localized in mitochondria. Plant Mol Biol 1997 Oct 1
14 9556058 Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 1998 Apr 1
15 9671773 Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 1998 Jul 21 1
16 9756921 Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression. J Biol Chem 1998 Oct 9 3
17 9758637 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins. Circ Res 1998 Oct 5 1
18 10026212 Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. J Biol Chem 1999 Feb 26 2
19 10205288 Effects of HMG-CoA reductase inhibition on PDGF- and angiotensin II- mediated signal transduction: suppression of c-Jun and c-Fos in human smooth muscle cells in vitro. Eur J Med Res 1999 Apr 27 2
20 10574973 Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase. J Biol Chem 1999 Dec 3 1
21 10688662 The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis. Mol Cell Biol 2000 Mar 1
22 10751437 Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. J Neurosci 2000 Apr 15 1
23 10988259 Fluvastatin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells. Hypertension 2000 Sep 1
24 10997696 Effect of lovastatin on small GTP binding proteins and on TGF-beta1 and fibronectin expression. Kidney Int Suppl 2000 Sep 2
25 11111075 Biochemical and genetic aspects of mevalonate kinase and its deficiency. Biochim Biophys Acta 2000 Dec 15 1
26 11141079 Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type II. Biochemistry 2001 Jan 9 10
27 11322384 Lovastatin blocks basic fibroblast growth factor-induced mitogen-activated protein kinase signaling in coronary smooth muscle cells via phosphatase inhibition. Eur J Cell Biol 2001 Mar 1
28 11334884 Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect. FEBS Lett 2001 Apr 27 2
29 11348105 Synthesis of farnesyl diphosphate analogues containing ether-linked photoactive benzophenones and their application in studies of protein prenyltransferases. J Org Chem 2001 May 18 2
30 11470741 Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study. Carcinogenesis 2001 Aug 1
31 11487529 Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). Br J Pharmacol 2001 Aug 2
32 11556795 Loss of alpha-tocopherol in tobacco plants with decreased geranylgeranyl reductase activity does not modify photosynthesis in optimal growth conditions but increases sensitivity to high-light stress. Planta 2001 Aug 1
33 11641412 Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate. J Biol Chem 2001 Dec 28 3
34 11675392 Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1. J Biol Chem 2001 Dec 28 3
35 11742861 Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2001 Dec 2
36 11882313 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. Atherosclerosis 2002 Mar 1
37 11950701 Cerivastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase, inhibits endothelial cell proliferation induced by angiogenic factors in vitro and angiogenesis in in vivo models. Arterioscler Thromb Vasc Biol 2002 Apr 1 3
38 12048120 Rho/Rho-kinase is involved in the synthesis of tissue factor in human monocytes. Atherosclerosis 2002 Jul 2
39 12063175 Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes. Biochim Biophys Acta 2002 Jun 12 2
40 12090904 HMG-CoA reductase inhibitors reduce interleukin-6 synthesis in human vascular smooth muscle cells. Cardiovasc Drugs Ther 2002 Mar 1
41 12208470 Regulation of interleukin-8 expression by HMG-CoA reductase inhibitors in human vascular smooth muscle cells. Atherosclerosis 2002 Nov 1
42 12226265 Specific Prenylation of Tomato Rab Proteins by Geranylgeranyl Type-II Transferase Requires a Conserved Cysteine-Cysteine Motif. Plant Physiol 1996 Apr 2
43 12384510 Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway. J Biol Chem 2002 Dec 20 1
44 12386146 Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury. Circ Res 2002 Oct 18 1
45 12410604 Effects of prenyl pyrophosphates on the binding of S-Ras proteins with KSR. J Exp Zool 2002 Nov 1 1
46 12427032 Isoprenoids influence expression of Ras and Ras-related proteins. Biochemistry 2002 Nov 19 1
47 12501010 Cerivastatin, a HMG-CoA reductase inhibitor, reduces plasminogen activator inhibitor-1 (PAI-1) expression in endothelial cells by down-regulation of cellular signaling and the inhibition of PAI-1 promoter activity. Jpn J Pharmacol 2002 Dec 2
48 12512694 Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis. J Physiol Pharmacol 2002 Dec 1
49 12538631 Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation. Endocrinology 2003 Feb 2
50 12548094 Effect of atorvastatin on adhesive phenotype of human endothelial cells activated by tumor necrosis factor alpha. J Cardiovasc Pharmacol 2003 Feb 1