Title : Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells.

Pub. Date : 1999 Jan 14

PMID : 9927194






14 Functional Relationships(s)
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1 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. Paclitaxel mitogen-activated protein kinase 8 Homo sapiens
2 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. Paclitaxel mitogen-activated protein kinase 8 Homo sapiens
3 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. Colchicine mitogen-activated protein kinase 8 Homo sapiens
4 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. Colchicine mitogen-activated protein kinase 8 Homo sapiens
5 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. BADS mitogen-activated protein kinase 8 Homo sapiens
6 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. BADS mitogen-activated protein kinase 8 Homo sapiens
7 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. Vincristine mitogen-activated protein kinase 8 Homo sapiens
8 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. Vincristine mitogen-activated protein kinase 8 Homo sapiens
9 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. Podophyllotoxin mitogen-activated protein kinase 8 Homo sapiens
10 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. Podophyllotoxin mitogen-activated protein kinase 8 Homo sapiens
11 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. Nocodazole mitogen-activated protein kinase 8 Homo sapiens
12 Treatment with taxol, colchicine, or other MBAs (vincristine, podophyllotoxin, nocodazole) stimulated the activity of c-jun N-terminal kinase 1 (JNK1) in MCF-7 cells. Nocodazole mitogen-activated protein kinase 8 Homo sapiens
13 However, BAPTA/AM, a specific intracellular Ca2+ chelator, attenuated JNK1 activation by taxol but not by colchicine, and had no effect on microtubule changes induced by taxol. 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid mitogen-activated protein kinase 8 Homo sapiens
14 However, BAPTA/AM, a specific intracellular Ca2+ chelator, attenuated JNK1 activation by taxol but not by colchicine, and had no effect on microtubule changes induced by taxol. Paclitaxel mitogen-activated protein kinase 8 Homo sapiens