Title : Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.

Pub. Date : 1998 Dec 22

PMID : 9922143






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The structure of this inhibitor bound to PTP1B represents the first crystal structure of a non-phosphonate-containing inhibitor and reveals the mechanism of phosphotyrosine mimicry by the fluoromalonyl tyrosine residue and the nature of its interactions within the catalytic site of PTP1B. Organophosphonates protein tyrosine phosphatase non-receptor type 1 Homo sapiens
2 The structure of this inhibitor bound to PTP1B represents the first crystal structure of a non-phosphonate-containing inhibitor and reveals the mechanism of phosphotyrosine mimicry by the fluoromalonyl tyrosine residue and the nature of its interactions within the catalytic site of PTP1B. Organophosphonates protein tyrosine phosphatase non-receptor type 1 Homo sapiens