Title : Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and v-ErbA-related protein 3.

Pub. Date : 1999 Feb 1

PMID : 9917326






7 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The 6betaB-A site shows a high degree of similarity to a consensus sequence of the binding site of hepatocyte nuclear factor 4 (HNF-4) and also to the 6betaA-A site on the rat CYP3A2 gene promoter region. 6betab-a cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 The 6betaB-A site shows a high degree of similarity to a consensus sequence of the binding site of hepatocyte nuclear factor 4 (HNF-4) and also to the 6betaA-A site on the rat CYP3A2 gene promoter region. 6betaa-a cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
3 Our previous study suggested an involvement of the 6betaA-A site in the basal transactivation of CYP3A2 gene using HepG2 cells. 6betaa-a cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
4 In the present study, transactivation through the 6betaB-A and 6betaA-A sites of CYP3A1 and CYP3A2 genes has directly been shown by coexpression of HNF-4 and CYP3A1 or CYP3A2 promoter-reporter fused genes. 6betab-a cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
5 In the present study, transactivation through the 6betaB-A and 6betaA-A sites of CYP3A1 and CYP3A2 genes has directly been shown by coexpression of HNF-4 and CYP3A1 or CYP3A2 promoter-reporter fused genes. 6betab-a cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
6 In the present study, transactivation through the 6betaB-A and 6betaA-A sites of CYP3A1 and CYP3A2 genes has directly been shown by coexpression of HNF-4 and CYP3A1 or CYP3A2 promoter-reporter fused genes. 6betaa-a cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
7 In the present study, transactivation through the 6betaB-A and 6betaA-A sites of CYP3A1 and CYP3A2 genes has directly been shown by coexpression of HNF-4 and CYP3A1 or CYP3A2 promoter-reporter fused genes. 6betaa-a cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus