Pub. Date : 1998 Sep
PMID : 9848110
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Three human liver UDP-glucuronosyltransferases, UGT2B7, UGT1A1, and UGT1A3, have been shown to catalyze the glucuronidation of catechol estrogens and lead to their enhanced elimination via urine or bile. | catechol | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 2 | UGT2B7(Y) reacted with higher efficiency toward 4-hydroxyestrogenic catechols, whereas UGT1A1 and UGT1A3 showed higher activities toward 2-hydroxyestrogens. | Catechols | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 3 | UGT2B7(H) catalyzed estrogen catechol glucuronidation with efficiencies similar to UGT2B7(Y). | catechol | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 4 | Flunitrazepam (FNZ), a competitive inhibitor of morphine glucuronidation in hepatic microsomes, competitively inhibited catechol estrogen glucuronidation catalyzed by UGT2B7(Y), UGT1A1, and UGT1A3. | Flunitrazepam | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 5 | Flunitrazepam (FNZ), a competitive inhibitor of morphine glucuronidation in hepatic microsomes, competitively inhibited catechol estrogen glucuronidation catalyzed by UGT2B7(Y), UGT1A1, and UGT1A3. | Morphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 6 | Flunitrazepam (FNZ), a competitive inhibitor of morphine glucuronidation in hepatic microsomes, competitively inhibited catechol estrogen glucuronidation catalyzed by UGT2B7(Y), UGT1A1, and UGT1A3. | catechol | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 7 | FNZ competitively inhibited buprenorphine glucuronidation with UGT1A1 and UGT2B7 but had no inhibitory activity toward UGT1A3. | Buprenorphine | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |