Title : Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.

Pub. Date : 1998 Nov 15

PMID : 9808574






1 Functional Relationships(s)
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1 We evaluated flavopiridol"s dependence on intact p53 by exposing splenocytes from wild-type (p53(+/+)) and p53 null (p53(-/-)) mice that demonstrated no preferential cytotoxicity as compared with a marked differential with F-ara-a and radiation. alvocidib transformation related protein 53, pseudogene Mus musculus