Title : Inhibition of p53-dependent apoptosis by the KIT tyrosine kinase: regulation of mitochondrial permeability transition and reactive oxygen species generation.

Pub. Date : 1998 Oct 1

PMID : 9796694






4 Functional Relationships(s)
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1 Inhibition of p53-dependent apoptosis by the KIT tyrosine kinase: regulation of mitochondrial permeability transition and reactive oxygen species generation. Reactive Oxygen Species transformation related protein 53, pseudogene Mus musculus
2 In this report we find that p53-dependent apoptosis proceeds through a pathway involving depolarization of the mitochondrial electropotential gradient (delta(psi)m) and the generation of reactive oxygen species (ROS). Reactive Oxygen Species transformation related protein 53, pseudogene Mus musculus
3 In this report we find that p53-dependent apoptosis proceeds through a pathway involving depolarization of the mitochondrial electropotential gradient (delta(psi)m) and the generation of reactive oxygen species (ROS). Reactive Oxygen Species transformation related protein 53, pseudogene Mus musculus
4 KIT activation suppresses p53-induced apoptosis in the mouse DP16 Friend erythroleukemia cell line by preventing delta(psi)m depolarization and ROS generation. Reactive Oxygen Species transformation related protein 53, pseudogene Mus musculus