Pub. Date : 1998 Nov
PMID : 9792916
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 fibroblasts. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 fibroblasts. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Lysophosphatidic acid (LPA) induced activation of c-Jun N-terminal kinase (JNK) in Swiss 3T3 fibroblasts. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Lysophosphatidic acid (LPA) induced activation of c-Jun N-terminal kinase (JNK) in Swiss 3T3 fibroblasts. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Lysophosphatidic acid (LPA) induced activation of c-Jun N-terminal kinase (JNK) in Swiss 3T3 fibroblasts. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | Lysophosphatidic acid (LPA) induced activation of c-Jun N-terminal kinase (JNK) in Swiss 3T3 fibroblasts. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | LPA-induced activation of JNK was not suppressed by prior treatment of the cells with pertussis toxin, whereas it was completely blocked by suramin, a non-selective inhibitor of ligand-receptor interactions. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | LPA-induced activation of JNK was not suppressed by prior treatment of the cells with pertussis toxin, whereas it was completely blocked by suramin, a non-selective inhibitor of ligand-receptor interactions. | Suramin | mitogen-activated protein kinase 8 | Homo sapiens |
| 9 | The kinetics and concentration-dependency of LPA-induced JNK activation were in sharp contrast with those of LPA-induced extracellular signal-regulated kinase (ERK) activation, which reached the maximum within 3 min and occurred with an EC50 of 0.1 microg/ml. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 10 | These results indicate that the signal transduction pathways of LPA-induced JNK and ERK activations are distinct. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 11 | Thus, this is the first report showing that LPA induces not only ERK activation but also JNK activation, which may be responsible for the induction of DNA synthesis in LPA-stimulated Swiss 3T3 fibroblasts. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 12 | Thus, this is the first report showing that LPA induces not only ERK activation but also JNK activation, which may be responsible for the induction of DNA synthesis in LPA-stimulated Swiss 3T3 fibroblasts. | lysophosphatidic acid | mitogen-activated protein kinase 8 | Homo sapiens |