Pub. Date : 1998 Oct 9
PMID : 9790925
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study we identify a selective and potent antisense oligonucleotide to RhoA (ISIS 17131) and investigate its effect on JNK activation induced by IL-1beta and H2O2 in A549 cells. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | The RhoA antisense oligonucleotide was able to inhibit JNK activation when A549 cells were stimulated by H2O2, but did not have any effect on IL-1beta induced JNK activation. | Oligonucleotides | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | The RhoA antisense oligonucleotide was able to inhibit JNK activation when A549 cells were stimulated by H2O2, but did not have any effect on IL-1beta induced JNK activation. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Additionally, Wortmannin, a potent inhibitor of the PI 3-kinase and phospholipase A2 (PLA2), and AACOCF3, also a PLA2 inhibitor, were able to inhibit JNK activation induced by H2O2, but they had no effect on JNK activation when stimulated by IL-1beta. | Wortmannin | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Additionally, Wortmannin, a potent inhibitor of the PI 3-kinase and phospholipase A2 (PLA2), and AACOCF3, also a PLA2 inhibitor, were able to inhibit JNK activation induced by H2O2, but they had no effect on JNK activation when stimulated by IL-1beta. | Wortmannin | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | Additionally, Wortmannin, a potent inhibitor of the PI 3-kinase and phospholipase A2 (PLA2), and AACOCF3, also a PLA2 inhibitor, were able to inhibit JNK activation induced by H2O2, but they had no effect on JNK activation when stimulated by IL-1beta. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | Additionally, Wortmannin, a potent inhibitor of the PI 3-kinase and phospholipase A2 (PLA2), and AACOCF3, also a PLA2 inhibitor, were able to inhibit JNK activation induced by H2O2, but they had no effect on JNK activation when stimulated by IL-1beta. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | These results suggest that, in A549, IL-1beta and H2O2 induce JNK activation by two independent pathways. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |