Title : Analysis of human breast adenocarcinoma MCF7 resistance to tumor necrosis factor-induced cell death. Lack of correlation between JNK activation and ceramide pathway.

Pub. Date : 1998 Oct 30

PMID : 9786905






1 Functional Relationships(s)
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1 We also demonstrated that JNK activation does not require ceramide generation since in MCF7 cells transfected with a dominant-negative derivative of FADD (FADD-DN), which are resistant to the cytotoxic action of TNF, TNF induced JNK activation in the absence of ceramide generation. Ceramides mitogen-activated protein kinase 8 Homo sapiens