Title : 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins.

Pub. Date : 1998 Oct 5

PMID : 9758637






1 Functional Relationships(s)
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1 The effects of HRI were reversed by mevalonate and geranylgeranyl pyrophosphate, but not by LDL cholesterol and farnesyl pyrophosphate, and were not induced by alpha-hydroxyfarnesyl phosphonic acid, an inhibitor of protein farnesyl transferase. geranylgeranyl pyrophosphate eukaryotic translation initiation factor 2 alpha kinase 1 Rattus norvegicus