Pub. Date : 1998 Oct
PMID : 9751169
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ca2+-mediated activation of c-Jun N-terminal kinase and nuclear factor kappa B by NMDA in cortical cell cultures. | N-Methylaspartate | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | We examined the possibility that c-Jun N-terminal kinase (JNK) and nuclear factor kappaB (NF-kappaB) might be involved in intracellular signaling cascades that mediate NMDA-initiated neuronal events. | N-Methylaspartate | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | We examined the possibility that c-Jun N-terminal kinase (JNK) and nuclear factor kappaB (NF-kappaB) might be involved in intracellular signaling cascades that mediate NMDA-initiated neuronal events. | N-Methylaspartate | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Exposure of cortical neurons to 100 microM NMDA induced activation of JNK within 1 min. | N-Methylaspartate | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Similarly, ionomycin, a selective Ca2+ ionophore, induced activation of JNK. | Ionomycin | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | The NMDA-induced activation of JNK was abrogated in the absence of extracellular Ca2+, suggesting that Ca2+ entry is necessary and sufficient for the JNK activation. | N-Methylaspartate | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | The NMDA-induced activation of JNK was abrogated in the absence of extracellular Ca2+, suggesting that Ca2+ entry is necessary and sufficient for the JNK activation. | N-Methylaspartate | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | Treatment with 3 mM aspirin blocked the NMDA-induced activation of JNK and NF-kappaB. | Aspirin | mitogen-activated protein kinase 8 | Homo sapiens |
| 9 | Treatment with 3 mM aspirin blocked the NMDA-induced activation of JNK and NF-kappaB. | N-Methylaspartate | mitogen-activated protein kinase 8 | Homo sapiens |
| 10 | The present study suggests that Ca2+ influx is required for NMDA-induced activation of JNK and NF-kappaB as well as NMDA neurotoxicity. | N-Methylaspartate | mitogen-activated protein kinase 8 | Homo sapiens |
| 11 | This study also implies that aspirin may exert its neuroprotective action against NMDA through blocking the NMDA-induced activation of NF-kappaB and JNK. | Aspirin | mitogen-activated protein kinase 8 | Homo sapiens |
| 12 | This study also implies that aspirin may exert its neuroprotective action against NMDA through blocking the NMDA-induced activation of NF-kappaB and JNK. | N-Methylaspartate | mitogen-activated protein kinase 8 | Homo sapiens |
| 13 | This study also implies that aspirin may exert its neuroprotective action against NMDA through blocking the NMDA-induced activation of NF-kappaB and JNK. | N-Methylaspartate | mitogen-activated protein kinase 8 | Homo sapiens |