Title : High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele.

Pub. Date : 1998 Sep 1

PMID : 9731488






4 Functional Relationships(s)
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1 High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele. Butylhydroxybutylnitrosamine transformation related protein 53, pseudogene Mus musculus
2 We have investigated the susceptibility of heterozygote p53 knockout mice to N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in terms of urinary bladder tumor induction. Butylhydroxybutylnitrosamine transformation related protein 53, pseudogene Mus musculus
3 We have investigated the susceptibility of heterozygote p53 knockout mice to N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in terms of urinary bladder tumor induction. Butylhydroxybutylnitrosamine transformation related protein 53, pseudogene Mus musculus
4 The high susceptibility of p53 knockout mice appeared to be related to the high level of cell proliferation rather than that of N-butyl-N-(3-carboxypropyl)nitrosamine in the urine or that of mutations at the p53 gene. butyl(3-carboxypropyl)nitrosamine transformation related protein 53, pseudogene Mus musculus