Title : D1 dopamine receptor agonists mediate activation of p38 mitogen-activated protein kinase and c-Jun amino-terminal kinase by a protein kinase A-dependent mechanism in SK-N-MC human neuroblastoma cells.

Pub. Date : 1998 Sep

PMID : 9730903






5 Functional Relationships(s)
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1 D1 dopamine receptor agonists mediate activation of p38 mitogen-activated protein kinase and c-Jun amino-terminal kinase by a protein kinase A-dependent mechanism in SK-N-MC human neuroblastoma cells. sk-n-mc mitogen-activated protein kinase 8 Homo sapiens
2 We found that the D1 dopamine receptor agonist SKF38393 induced similar time- and dose-related activation of p38 MAPK and c-Jun amino-terminal kinase (JNK), whereas extracellular signal-regulated kinase activity was not affected by D1 dopamine receptor stimulation. 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine mitogen-activated protein kinase 8 Homo sapiens
3 Maximal stimulation of p38 MAPK and JNK was observed after a 15-min incubation with 100 microM SKF38393. 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine mitogen-activated protein kinase 8 Homo sapiens
4 Furthermore, dibutyryl-cAMP mimicked SKF38393-mediated stimulation of p38 MAPK and JNK. Bucladesine mitogen-activated protein kinase 8 Homo sapiens
5 Furthermore, dibutyryl-cAMP mimicked SKF38393-mediated stimulation of p38 MAPK and JNK. 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine mitogen-activated protein kinase 8 Homo sapiens