Pub. Date : 1998 Jul-Aug
PMID : 9715507
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Carcinogenic responses of transgenic heterozygous p53 knockout mice to inhaled 239PuO2 or metallic beryllium. | plutonium dioxide | transformation related protein 53, pseudogene | Mus musculus |
| 2 | Carcinogenic responses of transgenic heterozygous p53 knockout mice to inhaled 239PuO2 or metallic beryllium. | Beryllium | transformation related protein 53, pseudogene | Mus musculus |
| 3 | Eleven of the p53+/- mice inhaling 239PuO2 developed pulmonary neoplasms. | plutonium dioxide | transformation related protein 53, pseudogene | Mus musculus |
| 4 | Seven p53+/+ mice exposed to 239PuO2 also developed pulmonary neoplasms, but the latency period for pulmonary neoplasia was significantly shorter in the p53+/ mice. | plutonium dioxide | transformation related protein 53, pseudogene | Mus musculus |
| 5 | Four pulmonary neoplasms were observed in p53+/- mice exposed to the higher dose of Be, whereas none were observed in the wild-type mice or in the heterozygous mice exposed to the lower dose of Be. | Beryllium | transformation related protein 53, pseudogene | Mus musculus |
| 6 | Thus, both p53+/- and p53+/+ mice were susceptible to 239Pu-induced carcinogenesis, whereas the p53+/- but not the p53+/+ mice were susceptible to Be-induced carcinogenesis. | Plutonium-239 | transformation related protein 53, pseudogene | Mus musculus |