Title : Uteroglobin (UG) suppresses extracellular matrix invasion by normal and cancer cells that express the high affinity UG-binding proteins.

Pub. Date : 1998 Aug 28

PMID : 9712916






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Uteroglobin (UG) is a steroid-inducible, multifunctional, secreted protein with antiinflammatory and antichemotactic properties. Steroids secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus
2 Uteroglobin (UG) is a steroid-inducible, multifunctional, secreted protein with antiinflammatory and antichemotactic properties. Steroids secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus
3 Since UG is a homodimer in which the 70 amino acid subunits are connected by two disulfide bonds, we sought to determine whether UG monomers also interact with the 190-kDa UG-binding protein and if so, whether it has the same biological activity as the dimer. Disulfides secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus
4 Treatment of the NIH 3T3 cells with specific cytokines (i.e. interleukin-6) and other agonists (i.e. lipopolysaccharide) caused a substantially increased level of 125I-UG binding but the same cells, when treated with platelet-derived growth factor, tumor necrosis factor-alpha, interferon-gamma, and phorbol 12-myristate 13-acetate, did not alter the UG binding. Tetradecanoylphorbol Acetate secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus