Pub. Date : 1998 Jun
PMID : 9708877
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Among the P450-dependent monooxygenase activities, testosterone 2alpha-hydroxylase (T2AH) and testosterone 6beta-hydroxylase (T6BH) activities, which are associated with CYP2C11 and CYP3A2 respectively, were remarkably decreased by 40 mg/kg BPA. | bisphenol A | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 2 | Among the P450-dependent monooxygenase activities, testosterone 2alpha-hydroxylase (T2AH) and testosterone 6beta-hydroxylase (T6BH) activities, which are associated with CYP2C11 and CYP3A2 respectively, were remarkably decreased by 40 mg/kg BPA. | bisphenol A | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 3 | Among the P450-dependent monooxygenase activities, testosterone 2alpha-hydroxylase (T2AH) and testosterone 6beta-hydroxylase (T6BH) activities, which are associated with CYP2C11 and CYP3A2 respectively, were remarkably decreased by 40 mg/kg BPA. | bisphenol A | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 4 | Furthermore, immunoblotting showed that BPA (20 or 40 mg/kg) significantly reduced CYP2C 11/6 and CYP3A2/1 protein levels in rat liver microsomes. | bisphenol A | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 5 | The Km values for T2AH and T6BH in 20 and 40 mg/kg BPA-treated rats were significantly high compared with that in control rats. | bisphenol A | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 6 | The Vmax for T2AH was dose-dependently decreased by BPA treatment, whereas that of T6BH was only decreased by BPA at 40 mg/kg. | bisphenol A | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |