Pub. Date : 1998 Aug
PMID : 9707514
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously demonstrated that the marine toxin and skin tumor promoter palytoxin activates the stress-activated protein kinase/c-Jun N-terminal kinase (JNK), but not the extracellular signal-regulated kinase (ERK), which is typically activated by mitogenic agents. | palytoxin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Using HeLa and COS7 cells, we found that, although there are similarities between the protein kinase cascades by which palytoxin and ouabain activate JNK, there are also significant differences between the activation of specific MAP kinases by palytoxin and ouabain. | palytoxin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Using HeLa and COS7 cells, we found that, although there are similarities between the protein kinase cascades by which palytoxin and ouabain activate JNK, there are also significant differences between the activation of specific MAP kinases by palytoxin and ouabain. | Ouabain | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Transient expression of dominant negative mutants indicates that ouabain, like palytoxin, activates JNK through a protein kinase cascade that involves the JNK kinase SEK1 but does not require the GTPase Ras. | palytoxin | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Transient expression of dominant negative mutants indicates that ouabain, like palytoxin, activates JNK through a protein kinase cascade that involves the JNK kinase SEK1 but does not require the GTPase Ras. | palytoxin | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | Palytoxin activates JNK and p38 to a greater extent than ouabain. | palytoxin | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | Ouabain blocked palytoxin-stimulated activation of JNK and p38, but not anisomycin-stimulated activation of these kinases, supporting the conclusion that ouabain and palytoxin bind to the same site on the Na+,K+-ATPase. | palytoxin | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | Ouabain blocked palytoxin-stimulated activation of JNK and p38, but not anisomycin-stimulated activation of these kinases, supporting the conclusion that ouabain and palytoxin bind to the same site on the Na+,K+-ATPase. | Ouabain | mitogen-activated protein kinase 8 | Homo sapiens |
| 9 | Ouabain blocked palytoxin-stimulated activation of JNK and p38, but not anisomycin-stimulated activation of these kinases, supporting the conclusion that ouabain and palytoxin bind to the same site on the Na+,K+-ATPase. | palytoxin | mitogen-activated protein kinase 8 | Homo sapiens |