Title : Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution.

Pub. Date : 1998 Jun

PMID : 9653550






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 RESULTS: The SAP kinases SAPK1 gamma/JNK1, SAPK3 and SAPK4 are not inhibited by SB 203580, because they have methionine in the position equivalent to Thr106 in the ATP-binding region of SAPK2a/p38 and SAPK2b/p38 beta 2. Methionine mitogen-activated protein kinase 8 Homo sapiens
2 RESULTS: The SAP kinases SAPK1 gamma/JNK1, SAPK3 and SAPK4 are not inhibited by SB 203580, because they have methionine in the position equivalent to Thr106 in the ATP-binding region of SAPK2a/p38 and SAPK2b/p38 beta 2. Adenosine Triphosphate mitogen-activated protein kinase 8 Homo sapiens