Pub. Date : 1998 May-Jun
PMID : 9608642
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Predominant p53 G-->A transition mutation and enhanced cell proliferation in uterine sarcomas of CBA mice treated with 1,2-dimethylhydrazine. | 1,2-Dimethylhydrazine | transformation related protein 53, pseudogene | Mus musculus |
| 2 | There was 100% correlation between p53 protein immunopositivity and subsequent detection of p53 mutations in DMH-induced malignant fibrous histiocytomas. | Dimethylhydrazines | transformation related protein 53, pseudogene | Mus musculus |
| 3 | There was 100% correlation between p53 protein immunopositivity and subsequent detection of p53 mutations in DMH-induced malignant fibrous histiocytomas. | Dimethylhydrazines | transformation related protein 53, pseudogene | Mus musculus |
| 4 | DMH-induced uterine MFH with p53 mutations also had a higher proliferative rate (qualitatively evaluated by immunohistochemical detection of proliferating cell nuclear antigen) when compared with other DMH-induced sarcomas. | Dimethylhydrazines | transformation related protein 53, pseudogene | Mus musculus |
| 5 | Our data suggest that DMH-induced uterine sarcomas are not consistent with smooth muscle cell origin and that a subset of these tumors, specifically DMH-induced malignant fibrous histiocytomas, have unique p53 G:C-->A:T transitions and a high proliferative rate. | Dimethylhydrazines | transformation related protein 53, pseudogene | Mus musculus |