Title : p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells.

Pub. Date : 1998 May 26

PMID : 9600935






7 Functional Relationships(s)
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1 p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells. Cisplatin transformation related protein 53, pseudogene Mus musculus
2 One factor that could explain the efficacy of cisplatin is the low frequency of p53 mutations observed in this tumor type. Cisplatin transformation related protein 53, pseudogene Mus musculus
3 Cisplatin treatment of teratocarcinoma cells with a wild-type p53 gene resulted in accumulation of the p53 protein through posttranscriptional mechanisms; induction of p53-target genes was also observed. Cisplatin transformation related protein 53, pseudogene Mus musculus
4 Cisplatin treatment of teratocarcinoma cells with a wild-type p53 gene resulted in accumulation of the p53 protein through posttranscriptional mechanisms; induction of p53-target genes was also observed. Cisplatin transformation related protein 53, pseudogene Mus musculus
5 Cisplatin treatment of teratocarcinoma cells with a wild-type p53 gene resulted in accumulation of the p53 protein through posttranscriptional mechanisms; induction of p53-target genes was also observed. Cisplatin transformation related protein 53, pseudogene Mus musculus
6 These experiments suggest that cisplatin inhibits cellular proliferation of testicular teratocarcinoma cells by two possible mechanisms, p53-dependent apoptosis and p53-independent cell cycle arrest. Cisplatin transformation related protein 53, pseudogene Mus musculus
7 These experiments suggest that cisplatin inhibits cellular proliferation of testicular teratocarcinoma cells by two possible mechanisms, p53-dependent apoptosis and p53-independent cell cycle arrest. Cisplatin transformation related protein 53, pseudogene Mus musculus