Title : The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs).

Pub. Date : 1998 Apr 10

PMID : 9598985






2 Functional Relationships(s)
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1 Three peaks of SAPK/JNK activity were separated by anion exchange chromatography, eluting in the isocratic wash (44 kDa), and at 0.08 M (46 and 52 kDa) and 0.15 M NaCl (54 kDa). Sodium Chloride mitogen-activated protein kinase 8 Homo sapiens
2 Since JNK1 antibodies immunoprecipitate the 46 kDa activity, this indicates that SB203580 selectively inhibits 52 and 54 kDa SAPKs/JNKs. SB 203580 mitogen-activated protein kinase 8 Homo sapiens