Pub. Date : 1998 Mar 30
PMID : 9533766
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 2-Deoxyglucose inhibits chemotherapeutic drug-induced apoptosis in human monocytic leukemia U937 cells with inhibition of c-Jun N-terminal kinase 1/stress-activated protein kinase activation. | Deoxyglucose | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | 2DG inhibited the etoposide-induced activation of c-Jun N-terminal kinase 1/stress-activated protein kinase (JNK1/SAPK) and the subsequent activation of CPP32, both of which are positive regulators for etoposide-induced apoptosis of U937 cells. | Deoxyglucose | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | 2DG inhibited the etoposide-induced activation of c-Jun N-terminal kinase 1/stress-activated protein kinase (JNK1/SAPK) and the subsequent activation of CPP32, both of which are positive regulators for etoposide-induced apoptosis of U937 cells. | Deoxyglucose | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | 2DG inhibited the etoposide-induced activation of c-Jun N-terminal kinase 1/stress-activated protein kinase (JNK1/SAPK) and the subsequent activation of CPP32, both of which are positive regulators for etoposide-induced apoptosis of U937 cells. | Etoposide | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | 2DG inhibited the etoposide-induced activation of c-Jun N-terminal kinase 1/stress-activated protein kinase (JNK1/SAPK) and the subsequent activation of CPP32, both of which are positive regulators for etoposide-induced apoptosis of U937 cells. | Etoposide | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | 2DG inhibited the etoposide-induced activation of c-Jun N-terminal kinase 1/stress-activated protein kinase (JNK1/SAPK) and the subsequent activation of CPP32, both of which are positive regulators for etoposide-induced apoptosis of U937 cells. | Etoposide | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | Our results indicate that 2DG inhibits apoptosis by blocking the signals from cellular DNA damage for JNK1/SAPK activation. | Deoxyglucose | mitogen-activated protein kinase 8 | Homo sapiens |