Pub. Date : 1998 Apr
PMID : 9528756
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anisomycin, a translational inhibitor secreted by Streptomyces spp., strongly activates the stress-activated mitogen-activated protein (MAP) kinases JNK/SAPK (c-Jun NH2-terminal kinase/stress-activated protein kinase) and p38/RK in mammalian cells, resulting in rapid induction of immediate-early (IE) genes in the nucleus. | Anisomycin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Further, we show that anisomycin-induced homologous desensitization is caused by the fact that anisomycin no longer activates the JNK/SAPK and p38/RK MAP kinase cascades in desensitized cells. | Anisomycin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Further, we show that anisomycin-induced homologous desensitization is caused by the fact that anisomycin no longer activates the JNK/SAPK and p38/RK MAP kinase cascades in desensitized cells. | Anisomycin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | In anisomycin-desensitized cells, activation of JNK/SAPKs by UV radiation and hyperosmolarity is almost completely lost, and that of the p38/RK cascade is reduced to about 50% of the normal response. | Anisomycin | mitogen-activated protein kinase 8 | Homo sapiens |