Title : Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase.

Pub. Date : 1998 Mar 3

PMID : 9482836






3 Functional Relationships(s)
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1 We demonstrate that JNK and ERK but not p38 phosphorylate GR in vitro primarily at Ser-246. Serine mitogen-activated protein kinase 8 Homo sapiens
2 Selective activation of either ERK or JNK in vivo inhibits GR-mediated transcriptional activation, which depends on receptor phosphorylation at Ser-246 by JNK but not ERK. Serine mitogen-activated protein kinase 8 Homo sapiens
3 Selective activation of either ERK or JNK in vivo inhibits GR-mediated transcriptional activation, which depends on receptor phosphorylation at Ser-246 by JNK but not ERK. Serine mitogen-activated protein kinase 8 Homo sapiens