Pub. Date : 1998 Feb 27
PMID : 9478967
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | C2-ceramide activates three distinct mitogen-activated protein kinases (MAPKs) in dermal fibroblasts, i.e. extracellular signal-regulated kinase 1/2 (ERK1/2), stress-activated protein kinase/Jun N-terminal-kinase (SAPK/JNK), and p38. | N-acetylsphingosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | C2-ceramide activates three distinct mitogen-activated protein kinases (MAPKs) in dermal fibroblasts, i.e. extracellular signal-regulated kinase 1/2 (ERK1/2), stress-activated protein kinase/Jun N-terminal-kinase (SAPK/JNK), and p38. | N-acetylsphingosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Activation of MMP-1 promoter by C2-ceramide is also effectively inhibited by kinase-deficient forms of ERK1/2 kinase (MEK1/2) activator Raf-1, ERK1 and ERK2, SAPK/JNK activator SEK1, or SAPKbeta. | N-acetylsphingosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | These results show that triggering the ceramide signaling pathway activates MMP-1 gene expression via three distinct MAPK pathways, i.e. ERK1/2, SAPK/JNK, and p38, and suggest that targeted modulation of the ceramide signaling pathway may offer a novel therapeutic approach for inhibiting collagenolytic activity, e.g. in inflammatory disorders. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |