Title : Ethosuximide is primarily metabolized by CYP3A when incubated with isolated rat liver microsomes.

Pub. Date : 1998 Jan

PMID : 9443857






2 Functional Relationships(s)
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1 Antibody inhibition experiments demonstrated ethosuximide metabolite levels for PB microsomes were not affected by CYP2B1 antibodies, whereas CYP3A2 antibodies reduced metabolite levels for both PB and CTZ microsomes by over 80%. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 Antibody inhibition experiments demonstrated ethosuximide metabolite levels for PB microsomes were not affected by CYP2B1 antibodies, whereas CYP3A2 antibodies reduced metabolite levels for both PB and CTZ microsomes by over 80%. Clotrimazole cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus