Title : The In vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes.

Pub. Date : 1997 Dec

PMID : 9399990






1 Functional Relationships(s)
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1 Antisera raised against rat CYP3A2 strongly inhibited quinine 3-hydroxylation by about 96, 84 and 92% with mouse, rat and dog liver microsomes, respectively, but neither anti-rat 2C11 and 2E1 antisera did so with rat liver microsomes. Quinine cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus