Title : Nitric oxide modulates the c-Jun N-terminal kinase/stress-activated protein kinase activity through activating c-Jun N-terminal kinase kinase.

Pub. Date : 1997 Nov 4

PMID : 9354637






12 Functional Relationships(s)
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1 Here, we demonstrate that nitric oxide induced the stimulation of c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase (SAPK) in intact cells. Nitric Oxide mitogen-activated protein kinase 8 Homo sapiens
2 Here, we demonstrate that nitric oxide induced the stimulation of c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase (SAPK) in intact cells. Nitric Oxide mitogen-activated protein kinase 8 Homo sapiens
3 Exposure of cultured HEK293 cells to sodium nitroprusside, a nitric oxide releasing agent, resulted in the stimulation of JNK1 activity. Nitroprusside mitogen-activated protein kinase 8 Homo sapiens
4 Exposure of cultured HEK293 cells to sodium nitroprusside, a nitric oxide releasing agent, resulted in the stimulation of JNK1 activity. Nitric Oxide mitogen-activated protein kinase 8 Homo sapiens
5 The sodium nitroprusside-induced stimulation of JNK1 activity was abolished by treatment of cells with N-acetylcysteine. Nitroprusside mitogen-activated protein kinase 8 Homo sapiens
6 The sodium nitroprusside-induced stimulation of JNK1 activity was abolished by treatment of cells with N-acetylcysteine. Acetylcysteine mitogen-activated protein kinase 8 Homo sapiens
7 Nitric oxide production from HEK293 cells ectopically expressing nitric oxide synthases resulted in the stimulation of JNK1 activity, while JNK1 stimulation in nitric oxide synthase-overexpressing cells was abrogated by a nitric oxide synthase inhibitor, NG-nitro-L-arginine. Nitric Oxide mitogen-activated protein kinase 8 Homo sapiens
8 Nitric oxide production from HEK293 cells ectopically expressing nitric oxide synthases resulted in the stimulation of JNK1 activity, while JNK1 stimulation in nitric oxide synthase-overexpressing cells was abrogated by a nitric oxide synthase inhibitor, NG-nitro-L-arginine. Nitric Oxide mitogen-activated protein kinase 8 Homo sapiens
9 Nitric oxide production from HEK293 cells ectopically expressing nitric oxide synthases resulted in the stimulation of JNK1 activity, while JNK1 stimulation in nitric oxide synthase-overexpressing cells was abrogated by a nitric oxide synthase inhibitor, NG-nitro-L-arginine. nitric mitogen-activated protein kinase 8 Homo sapiens
10 Nitric oxide production from HEK293 cells ectopically expressing nitric oxide synthases resulted in the stimulation of JNK1 activity, while JNK1 stimulation in nitric oxide synthase-overexpressing cells was abrogated by a nitric oxide synthase inhibitor, NG-nitro-L-arginine. Nitroarginine mitogen-activated protein kinase 8 Homo sapiens
11 Furthermore, exposure of cells to sodium nitroprusside resulted in the stimulation of JNK kinase (JNKK1/SEK1). Nitroprusside mitogen-activated protein kinase 8 Homo sapiens
12 Taken together, our data suggest that nitric oxide modulates the JNK activity through activating JNKK1/SEK1. Nitric Oxide mitogen-activated protein kinase 8 Homo sapiens